Acute effects of zaleplon on daytime functions on the following day: psychomotor and physical performances, arousal levels and mood
Acute effects of zaleplon on daytime functions on the following day: psychomotor and physical performances, arousal levels and mood
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DOI：
10.23736/s0393-3660.16.03353-2
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发表时间：
2017-05-01
影响因子：
0.1
通讯作者：
Nishino, Seiji
中科院分区：
文献类型：
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作者：
Ito, Wakako;Kanbayashi, Takashi;Nishino, Seiji
背景：睡眠问题是运动员经常遇到的问题。虽然服用催眠药是治疗失眠的方法之一，但使用这些药物的一个主要问题是后遗症。本研究的目的是评估扎来普隆对精神运动功能、体能、情绪和主观睡眠评估的残留影响。方法：采用随机、双盲、交叉设计，在11名运动员睡前单次口服扎来普隆(10 Mg)或安慰剂。结果：扎来普隆不影响主观睡眠评价、精神运动和身体活动(简单辨别反应、数字符号替代、手指敲击、前屈、右手握力、右股四头肌肌力和反复侧跳)，也不影响情绪(情绪状态)。视觉模拟评分在安慰剂条件下的警觉性评分在13：00h时显著低于9：00h和17：00h，而扎来普隆条件下的警觉性得分没有变化。临界闪烁融合试验(CFF)显示扎来普隆状态下的结果明显好于安慰剂状态下的结果。结论：这些结果表明扎来普隆可能提高了第二天的警觉水平，这可能是催眠药物的停用。然而，与安慰剂治疗相比，扎来普隆并没有损害任何评估。我们的结论是，在运动员中使用扎来普隆可能并不矛盾，因为它可以避免在体育赛事前一晚的睡眠干扰。
BACKGROUND: Sleep problems are commonly experienced by athletes. Although taking hypnotics is one of the treatments for insomnia, a major problem with use of these drugs is the residual effects. The aim of this study was to assess residual effects of zaleplon on psychomotor functions, physical performances, mood and subjective sleep evaluations.METHODS: Single oral doses of zaleplon (10 mg) or placebo was administered before going to bed in a randomized double-blind, cross-over design to eleven athletes. These assessments were conducted at 9: 00 h, 13: 00 h and 17: 00 h on the following day.RESULTS: Zaleplon did affect neither subjective sleep evaluations, psychomotor nor physical performances (simple discrimination reaction, digit symbol substitution, finger tapping, forward bending, right grip strength, right quadriceps femoris muscle strength, and repeated side jumps), nor mood (Profile of Mood State). The score of alertness with visual analog scale in placebo condition was significantly worse at 13: 00 h compared to 9: 00 h and 17: 00 h, while no changes were seen in the zaleplon condition. Critical flicker fusion test (CFF) showed significantly better results in the zaleplon condition than in the placebo condition across the day.CONCLUSIONS: These results indicated zaleplon may have enhanced the level of vigilance on the following day, which may be the withdrawal from the hypnotic. However, zaleplon did not impair any evaluations compared to the placebo session. We concluded that a use of zaleplon may not be contradicted in athletes for avoiding sleep disturbances the night before sports events.