Physics of protein-DNA interaction
Physics of protein-DNA interaction
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DOI：
10.1016/s0378-4371(02)01038-5
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发表时间：
2002-10-01
影响因子：
3.3
通讯作者：
Bruinsma, RF
中科院分区：
文献类型：
--
作者：
Bruinsma, RF
生命是基于两个生物聚合物家族之间的共生关系：由核酸组成的DNA和RNA，以及由氨基酸组成的蛋白质[1]。蛋白质是细胞的活性物质。它们控制着细胞内发生的生化反应的速率。它们负责遗传密码的转录，产生遗传密码短片段的拷贝，这些拷贝被用作产生新蛋白质的蓝图，以及遗传密码的复制，即，在细胞分裂过程中产生完整的遗传密码。其他大分子的合成，如脂质和糖，是由蛋白质进行的，我们肌肉的机械力是由擅长“机械化学”的专门蛋白质产生的，它们检测光，声音和气味，并保持细胞的结构完整性。
Life is based on a symbiotic relationship between two families of biopolymers: DNA and RNA, constituted of nucleic-acids, and proteins, constituted of amino-acids [1]. Proteins are the active agents of the cell. Asenzymes, they control theratesof biochemical reactions taking place inside the cell. They are responsible for thetranscriptionof the genetic code,i.e., the production of copies of short segments of the genetic code that are used as blue-prints for the production of new proteins, and for theduplicationof the genetic code,i.e., the production of a full copy of the genetic code during cell division. Synthesis of other macromolecules, such as lipids and sugars, is carried out by proteins, the mechanical force of our muscles is generated by specialized proteins adept at “mechano-chemistry”, they detect light, sound, and smell, and maintain the structural integrity of cells.