Extremely preterm infants receiving standard care receive very low levels of arachidonic and docosahexaenoic acids
Extremely preterm infants receiving standard care receive very low levels of arachidonic and docosahexaenoic acids
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DOI：
10.1016/j.clnu.2016.09.033
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发表时间：
2017-12-01
影响因子：
6.3
通讯作者：
Dyall, S. C.
中科院分区：
文献类型：
--
作者：
De Rooy, L.;Hamdallah, H.;Dyall, S. C.
背景与目的：足量的花生四烯酸（ARA）和二十二碳六烯酸（DHA）对大脑发育至关重要，极早产儿可能存在缺乏DHA的风险。虽然最近的证据表明DHA的摄入量可能会导致严重的缺陷，但目前给予极早产儿的ARA和DHA的水平以及可增加的量尚未确定。本研究量化了标准护理早产儿出生后6周内所有来源的omega-6和omega-3多不饱和脂肪酸（PUFA）摄入量。此外，我们还探讨了血液循环细胞因子水平与PUFAs之间的关系。方法：单中心纵向研究，从所有来源分析17名出生婴儿的omega-6和omega-3 PUFA摄入数据
Background & aims: Adequate supply of arachidonic (ARA) and docosahexaenoic (DHA) acids is essential for brain development, and extremely preterm infants may be at risk of deficiency. Current levels of ARA and DHA given to extremely preterm infants and the amounts available for accretion have not been established, although recent evidence suggests DHA intake is at a level likely to lead to severe deficits. This study quantified the omega-6 and omega-3 polyunsaturated fatty acid (PUFA) intakes from all sources in the first six weeks of life of preterm infants in standard care. In addition, the relationship between blood levels of circulating cytokines and PUFAs was explored.Methods: Single centre longitudinal study with omega-6 and omega-3 PUFA intake data analysed from all sources for 17 infants born