Tumorigenicity of EBV-carrying lymphoblastoid cell lines (LCLs): distinctive grading in SCID mice.
Tumorigenicity of EBV-carrying lymphoblastoid cell lines (LCLs): distinctive grading in SCID mice.
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携带 EBV 的淋巴母细胞系 (LCL) 的致瘤性：SCID 小鼠的独特分级。
DOI：
10.1002/ijc.2910490420
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发表时间：
1991
影响因子：
6.4
通讯作者：
Klein,G
中科院分区：
文献类型：
--
作者：
Ramqvist,T;Norén,L;Iwarsson,K;Klein,G
在SCID小鼠中平行研究了淋巴母细胞样细胞系（LCL）、伯基特淋巴瘤（BL）和PBL衍生的免疫母细胞瘤的体外和体内生长。大多数（但不是全部）检测的LCL在SCID小鼠中具有致瘤性。长期体外培养不是致瘤性的必要前提。在体内和体外生长之间有很好的相关性。细胞的三个主要类别可以根据其生长特性来区分。
Thein vitroand in vivo growth of lymphoblastoid cell lines (LCLs), Burkitt lymphomas (BLs) and PBL‐derived immunoblastomas in SCID mice was studied in parallel. Most, but not all, of the LCLs tested were tumorigenic in SCID mice. Long‐term culturingin vitrowas not a necessary prerequisite for tumorigenicity. There was a good correlation betweenin vivoandin vitrogrowth. Three major classes of cells could be distinguished on the basis of their growth properties.