DISTANTLY RELATED SEQUENCES IN THE ALPHA-SUBUNITS AND BETA-SUBUNITS OF ATP SYNTHASE, MYOSIN, KINASES AND OTHER ATP-REQUIRING ENZYMES AND A COMMON NUCLEOTIDE BINDING FOLD
DISTANTLY RELATED SEQUENCES IN THE ALPHA-SUBUNITS AND BETA-SUBUNITS OF ATP SYNTHASE, MYOSIN, KINASES AND OTHER ATP-REQUIRING ENZYMES AND A COMMON NUCLEOTIDE BINDING FOLD
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DOI：
10.1002/j.1460-2075.1982.tb01276.x
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发表时间：
1982-01-01
期刊：
影响因子：
11.4
通讯作者：
GAY, NJ
中科院分区：
文献类型：
--
作者：
WALKER, JE;SARASTE, M;GAY, NJ
α-和β-膜结合ATP合酶复合物的亚基结合ATP和ADP：有助于催化位点，和α.可能参与ATP合成酶活性的调节。β的序列-亚基在大肠杆菌和牛线粒体中高度保守。也是α。和β在它们的大部分氨基酸序列中彼此弱同源，这表明它们在催化中具有共同的功能。α和β中的相关序列和β以及在催化中结合ATP或ADP的其他酶，特别是肌球蛋白、磷酸果糖激酶和腺苷酸激酶中，有助于鉴定在两个ATP合酶亚基中对腺嘌呤核苷酸结合折叠有贡献的区域。
The .alpha.- and .beta.-subunits of membrane-bound ATP synthase complex bind ATP and ADP: .beta. contributes to catalytic sites, and .alpha. may be involved in regulation of ATP synthase activity. The sequences of .beta.-subunits are highly conserved in Escherichia coli and bovine mitochondria. Also .alpha. and .beta. are weakly homologous to each other throughout most of their amino acid sequences, suggesting that they have common functions in catalysis. Related sequences in both .alpha. and .beta. and in other enzymes that bind ATP or ADP in catalysis, notably myosin, phosphofructokinase, and adenylate kinase, help to identify regions contributing to an adenine nucleotide binding fold in both ATP synthase subunits.