Membrane lipid rafts and their role in axon guidance
Membrane lipid rafts and their role in axon guidance
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DOI：
10.1007/978-0-387-76715-4_11
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Zheng, James Q.
中科院分区：
文献类型：
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作者：
Guirland, Carmine;Zheng, James Q.
细胞的质膜包含多种脂质和蛋白质分子，这些分子通常是分离的，并且在微域中分布不均。脂筏代表了一种广义的膜微域概念，它富含胆固醇和鞘脂，并且具有抗冷洗涤剂提取的特点。脂筏最近受到了相当大的关注，因为它们被认为参与许多细胞功能，特别是细胞外刺激的信号转导。许多这些功能也与神经发育过程密切相关，包括神经营养因子信号传导和突触可塑性。最近我们实验室和其他人的研究表明脂筏在轴突生长和引导中的重要作用。具体来说，我们的数据表明，质膜上的脂筏为细胞外信号的空间和时间控制提供了平台。此外，脂筏也可能在轴突生长和引导的其他方面发挥作用，包括粘附、细胞骨架动力学和生长锥运动的时空调节。进一步阐明膜筏如何参与引导轴突生长，将为了解神经元布线背后复杂的信号机制提供重要见解，这是正常大脑发育和损伤和疾病后功能恢复的基础。
The plasma membrane of cells contains a variety of lipid and protein molecules that are often segregated and heterogeneously distributed in microdomains. Lipid rafts represent a generalized concept of membrane microdomains that are enriched in cholesterol and sphingolipids and, characteristically, resistant to cold detergent extraction. Lipid rafts have recently received considerable attention because they are thought to be involved in many cellular functions, in particular, signal transduction for extracellular stimuli. Many of these functions are also intimately related to the processes involved in neural development, including neurotrophic factor signaling and synaptic plasticity. Recent studies from our lab and others have indicated an important role for lipid rafts in axonal growth and guidance. Specifically, our data show that lipid rafts on the plasma membrane provide platforms for spatial and temporal control of guidance signaling by extracellular cues. In addition, lipid rafts may also function in other aspects of axonal growth and guidance, including spatial and temporal regulation of adhesion, cytoskeletal dynamics, and growth cone motility. Further elucidating how membrane rafts are involved in guided axonal growth would provide important insights into the intricate signaling mechanisms underlying neuronal wiring, which is fundamental for normal brain development and functional recovery after injury and diseases.