Biology of the TAM Receptors
Biology of the TAM Receptors
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DOI：
10.1101/cshperspect.a009076
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发表时间：
2013-11-01
影响因子：
7.2
通讯作者：
Lemke, Greg
中科院分区：
文献类型：
--
作者：
Lemke, Greg
The TAM receptors-Tyro3, Axl, and Mer-comprise a unique family of receptor tyrosine kinases, in that as a group they play no essential role in embryonic development. Instead, they function as homeostatic regulators in adult tissues and organ systems that are subject to continuous challenge and renewal throughout life. Their regulatory roles are prominent in the mature immune, reproductive, hematopoietic, vascular, and nervous systems. The TAMs and their ligands-Gas6 and Protein S-are essential for the efficient phagocytosis of apoptotic cells and membranes in these tissues; and in the immune system, theyact as pleiotropic inhibitors of the innate inflammatory response to pathogens. Deficiencies in TAM signaling are thought to contribute to chronic inflammatory and autoimmune disease in humans, and aberrantly elevated TAM signaling is strongly associated with cancer progression, metastasis, and resistance to targeted therapies.
