Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
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DOI：
10.1210/jc.2005-1303
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发表时间：
2006-02-01
影响因子：
5.8
通讯作者：
Guralnik, JM
中科院分区：
文献类型：
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作者：
Ferrucci, L;Cherubini, A;Guralnik, JM
目的：多不饱和脂肪酸（PUFA）摄入量高的人心血管疾病发病率和死亡率较低。 PUFA 的保护作用由多种机制介导，包括其抗炎特性。生理性 PUFA 水平与促炎和抗炎标志物的关联尚未确定。方法和结果：在 1123 名受试者（20 - 98 岁）中，我们检查了空腹血浆中脂肪酸相对浓度与炎症标志物水平之间的关系。调整年龄、性别和主要混杂因素后，较低的花生四烯酸和二十二碳六烯酸与显着较高的 IL-6 和 IL-1ra 以及显着较低的 TGF β 相关。较低的α-亚麻酸与较高的C反应蛋白和IL-1ra相关，较低的二十碳五烯酸与较高的IL-6和较低的TGFβ相关。较低的二十二碳六烯酸与较低的 IL-10 密切相关。总 n-3 脂肪酸与较低的 IL-6 (P = 0.005)、IL-1ra (P = 0.004) 和 TNF α (P = 0.040) 以及较高的可溶性 IL-6r (P = 0.001)、IL-10 (P = 0.024) 和 TGF beta (P = 0.0012) 相关。较低的 n-6 脂肪酸水平与较高的 IL-1ra (P = 0.026) 和较低的 TGF beta (P = 0.014) 显着相关。 n-6 与 n-3 的比率与 IL-10 呈强负相关。在没有心血管疾病的参与者中以及从协变量中排除脂质后，结果相似。结论：在这个基于社区的样本中，PUFA，尤其是总 n-3 脂肪酸，与较低水平的促炎标记物（IL-6、IL-1ra、TNF α、C-反应蛋白）和较高水平的抗炎标记物（可溶性标记物）独立相关。 IL-6r、IL-10、TGF beta) 独立于混杂因素。我们的研究结果支持这样的观点：n-3 脂肪酸可能对患有活动性炎症疾病的患者有益。
Aims: Persons with high intake of polyunsaturated fatty acids (PUFAs) have lower cardiovascular morbidity and mortality. The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established.Methods and Results: In 1123 persons (aged 20 - 98 yr), we examined the relationship between relative concentration of fatty acids in fasting plasma and level of inflammatory markers. Adjusting for age, sex, and major confounders, lower arachidonic and docosahexaenoic acids were associated with significantly higher IL-6 and IL-1ra and significantly lower TGF beta. Lower alpha-linolenic acid was associated with higher C-reactive protein and IL-1ra, and lower eicosapentaenoic acid was associated with higher IL-6 and lower TGF beta. Lower docosahexaenoic acid was strongly associated with lower IL-10. Total n-3 fatty acids were associated with lower IL-6 ( P = 0.005), IL-1ra ( P = 0.004), and TNF alpha ( P = 0.040) and higher soluble IL-6r ( P = 0.001), IL-10 ( P = 0.024), and TGF beta( P = 0.0012). Lower n-6 fatty acid levels were significantly associated with higher IL-1ra ( P = 0.026) and lower TGF beta( P = 0.014). The n-6 to n-3 ratio was a strong, negative correlate of IL-10. Findings were similar in participants free of cardiovascular diseases and after excluding lipids from covariates.Conclusions: In this community-based sample, PUFAs, and especially total n-3 fatty acids, were independently associated with lower levels of proinflammatory markers ( IL-6, IL-1ra, TNF alpha, C-reactive protein) and higher levels of antiinflammatory markers ( soluble IL-6r, IL-10, TGF beta) independent of confounders. Our findings support the notion that n-3 fatty acids may be beneficial in patients affected by diseases characterized by active inflammation.