BIDIRECTIONAL CLOSURE OF THE ROSTRAL NEUROPORE IN THE HUMAN-EMBRYO
BIDIRECTIONAL CLOSURE OF THE ROSTRAL NEUROPORE IN THE HUMAN-EMBRYO
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DOI：
10.1002/aja.1001840402
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发表时间：
1989-04-01
影响因子：
--
通讯作者：
MULLER, F
中科院分区：
文献类型：
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作者：
ORAHILLY, R;MULLER, F
在23个第10-12期（约22-26天）的人类胚胎中测量了每个神经孔的长度，并在24个第11期（约24天）的胚胎中研究了吻侧神经孔唇的闭合，特别是参考末端唇。从两个特别合适的实例中制备图形重建，并绘制其中一个的有丝分裂图。吻侧和尾侧神经孔的长度基本相似，但吻侧开口比尾侧开口（需要一天）早一天关闭，而且关闭更突然（几小时内）。在人类胚胎中，吻侧神经孔的闭合是双向的，同时从1）中脑和间脑2和2）邻近视交叉板的端脑区域进行。强调物种差异。在神经孔的末端唇处的闭合是通过左右神经褶的融合，就像在初级神经形成期间的其他地方发生的那样。在人类胚胎中，正中面神经板的吻端位于视交叉板的吻端。然而，组织学差异，存在于终端唇和背唇之间的关闭：表面上皮细胞起着更重要的作用，在终端唇，和接缝更明显，大概更强。在未来的无脑畸形中，已经发现，虽然在背唇的融合是不充分的，但在末端唇的融合可能会发生。
The length of each neuropore was measured in 23 human embryos of stages 10-12 (about 22-26 days), and the closure of the lips of the rostral neuropore was studied in 24 embryos of stage 11 (about 24 days), with particular reference to the terminal lip. Graphic reconstructions were prepared from two particularly suitable examples, and mitotic figures were plotted for one of these. The lengths of the rostral and caudal neuropores are basically similar, but the rostral opening closes 1 day earlier and more abruptly (within a few hours) than the caudal (which takes a day). Closure of the rostral neuropore in the human embryo is bidirectional, proceeding simultaneously from 1) midbrain and diencephalon 2 and 2) the telencephalic region adjacent to the chiasmatic plate. Species differences are emphasized. Closure at the terminal lip of the neuropore is by fusion of right and left neural folds, as occurs elsewhere during primary neurulation. The rostral end of the neural plate in the median plane is, in the human embryo, at the rostral limit of the chiasmatic plate. Histologic differences, however, exist between closure at the terminal lip and that at the dorsal lip: the surface epithelium plays a more significant role at the terminal lip, and the seam is more visible and presumably stronger. In future anencephaly it has been found that fusion at the terminal lip may occur, although that at the dorsal lip is deficient.