Ovine placental lactogen stimulation of ornithine decarboxylase activity in brain and liver of neonatal rats.
Ovine placental lactogen stimulation of ornithine decarboxylase activity in brain and liver of neonatal rats.
复制标题
羊胎盘催乳素刺激新生大鼠脑和肝中鸟氨酸脱羧酶活性。
DOI：
10.1016/0024-3205(78)90450-2
复制
发表时间：
1978
期刊：
影响因子：
6.1
通讯作者：
Stuart Handwerger
中科院分区：
文献类型：
--
作者：
Stephen R. Butler;Thomas Hurley;Saul M. Schanberg;Stuart Handwerger
将绵羊胎盘催乳素（oPL）、生长激素（oGH）、催乳素（oPRL）和人胎盘催乳素（hPL）脑池内（ic）或腹腔内（ip）给予17日龄大鼠，4小时后测定脑和肝ODC活性。当给予ic时，oPL、oGH和oPRL引起脑ODC活性显著增加，而hPL没有显著影响。ip给药后，oPL和oGH也引起脑和肝ODC活性的显著增加，但oPRL和hPL没有显著影响。多胺代谢的刺激oPL与早期报道的其有效的促生长作用和其在胎儿中的高浓度支持的假设，oPL可能是重要的胎儿生长的调节。
Ovine placental lactogen (oPL), growth hormone (oGH), prolactin (oPRL) and human placental lactogen (hPL) were administered intracisternally (ic) or intraperitoneally (ip) to 17 day old rats and brain and liver ODC activities determined four hours later. When given ic, oPL, oGH and oPRL caused significant increases in brain ODC activity, while hPL had no significant effect. After ip administration, oPL and oGH also caused a significant increase in brain as well as liver ODC activity but oPRL and hPL were without significant effect. The stimulation of polyamine metabolism by oPL together with earlier reports of its potent somatotropic effects and its high concentration in the fetus supports the hypothesis that oPL may be important in the regulation of fetal growth.