Clinical Syndromes Associated with Ovarian Neoplasms: A Comprehensive Review
Clinical Syndromes Associated with Ovarian Neoplasms: A Comprehensive Review
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DOI：
10.1148/rg.304095745
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发表时间：
2010-07-01
期刊：
影响因子：
5.5
通讯作者：
Menias, Christine O.
中科院分区：
文献类型：
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作者：
Shanbhogue, Alampady Krishna Prasad;Shanbhogue, Divyva Krishna Prasad;Menias, Christine O.
功能性卵巢肿瘤具有独特的临床表现，与激素过度分泌有关，并可引起广泛的临床综合征。性索间质肿瘤是最常见的功能性卵巢肿瘤，与雌激素过多（如颗粒细胞瘤和卵泡膜细胞瘤）或高雄激素过多（如支持-间质细胞瘤和间质细胞瘤）有关。其他不太常见的卵巢肿瘤可能有内分泌或非内分泌综合征表现，包括与人绒毛膜促性腺激素过度产生相关的生殖细胞肿瘤（如绒毛膜癌、无性细胞瘤）、与类癌综合征和甲状腺功能亢进相关的单胚层畸胎瘤（如类癌、卵巢甲状腺肿）以及与副肿瘤综合征相关的原发性上皮性卵巢癌。基于患者人口统计学信息、临床表现、实验室检查结果和横断面影像学特征的诊断算法的应用可能有助于在复杂的临床环境中识别卵巢肿瘤。
Functional ovarian neoplasms have unique clinical manifestations related to hormone overproduction and may give rise to a broad spectrum of clinical syndromes. Sex cord stromal tumors, the most common functional ovarian neoplasms, are associated with either hyperestrogenism (as in granulosa cell tumor and thecoma) or hyperandrogenism (as in Sertoli-Leydig cell tumor and Leydig cell tumor). Other, less common ovarian neoplasms that may have endocrine or nonendocrine syndromic manifestations include germ cell tumors associated with the excessive production of human chorionic gonadotropin (eg, choriocarcinoma, dysgerminoma), monodermal teratomas (eg, carcinoid tumor, struma ovarii) associated with carcinoid syndrome and hyperthyroidism, and primary epithelial ovarian cancers associated with paraneoplastic syndromes. The application of diagnostic algorithms based on patient demographic information, clinical manifestations, laboratory findings, and cross-sectional imaging features may help identify ovarian neoplasms in complex clinical settings.