Does depression increase the risk of developing type 2 diabetes?
Does depression increase the risk of developing type 2 diabetes?
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DOI：
10.1093/occmed/kqm105
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发表时间：
2008-01-01
影响因子：
5.1
通讯作者：
Griffin, Simon J.
中科院分区：
文献类型：
--
作者：
Cosgrove, Martin P.;Sargeant, Lincoln A.;Griffin, Simon J.
研究背景：工伤抚恤金计划的成员可能会声称糖尿病的发病是由工作引起的抑郁症引起的，以申请工伤奖励。目的：量化抑郁症和随后发展的2型糖尿病之间的关系，以确定是否应该向在工伤抚恤金计划中发展为2型糖尿病的个人授予工伤抚恤金，如果糖尿病的发展遵循与工作有关的抑郁epission.Methods电子和手文献检索到2006年12月。使用固定和随机效应模型汇总了成人队列研究的相对风险估计值。归因风险分数计算使用Levin formulation.Results抑郁或抑郁症状的存在与随后发展为2型糖尿病的风险增加。来自三项最高质量研究的合并完全校正的相对风险估计值为1.25（95% CI：1.02-1.48），具有同质性。然而，抑郁症是没有更频繁的流行，但以前未确诊的，2型diabetes.Conclusion抑郁症与随后的发展2型糖尿病。然而，相对风险估计很小，只有20%的糖尿病病例可归因于患有这两种疾病的人的抑郁症。需要进一步的研究来确定这种关联的可能的因果机制，并确定抑郁症和糖尿病是否可能有共同的病因。
Background Members of a scheme awarding injury pensions may allege that the onset of diabetes was precipitated or caused by depression induced by work in order to claim an injury award.Aims To quantify the association between depression and subsequent development of type 2 diabetes in order to determine whether an individual in a pension scheme that awards injury pensions, who develops type 2 diabetes, should be awarded an injury pension, if the development of the diabetes followed a work-related depressive episode.Methods Electronic and hand literature searches up to December 2006. Relative risk estimates from cohort studies of adults were pooled using fixed and random effects models. Attributable risk fraction was calculated using the Levin formula.Results The presence of depression or depressive symptoms was associated with increased risk of subsequently developing type 2 diabetes. The pooled fully adjusted relative risk estimate from the three highest quality studies was 1.25 (95% CI: 1.02-1.48) and was homogenous. However, depression was no more frequent among those with and without prevalent, but previously undiagnosed, type 2 diabetes.Conclusion Depression is associated with subsequent development of type 2 diabetes. However, the relative risk estimate is small and only 20% of cases of diabetes can be attributed to depression in people with both conditions. Further research is needed to determine possible causal mechanisms for the association and to ascertain whether depression and diabetes may have a common aetiology.