The role of acidity in solid tumour growth and invasion
The role of acidity in solid tumour growth and invasion
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DOI：
10.1016/j.jtbi.2005.02.001
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发表时间：
2005-08-21
影响因子：
2
通讯作者：
Maini, PK
中科院分区：
文献类型：
--
作者：
Smallbone, K;Gavaghan, DJ;Maini, PK
酸性酸碱度是人类肿瘤的共同特征。它对肿瘤的进展和对治疗的反应有重大影响。在这篇文章中，我们开发了一个简单的三维肿瘤生长模型来检查酸中毒在正常细胞和肿瘤细胞群体之间相互作用中的作用。我们研究了血管和非血管肿瘤的动力学，并观察到一些不同的行为。虽然无血管肿瘤总是进展到良性稳定状态，但血管肿瘤可以表现为良性或侵袭性动力学，这取决于关键参数的值。对模型的分析使我们能够评估针对改变肿瘤内酸度水平的新疗法。(C)2005爱思唯尔有限公司。保留所有权利。
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the interaction between normal and tumour cell populations. Both vascular and avascular tumour dynamics are investigated, and a number of different behaviours are observed. Whilst an avascular tumour always proceeds to a benign steady state, a vascular tumour may display either benign or invasive dynamics, depending on the value of a critical parameter. Analysis of the model allows us to assess novel therapies directed towards changing the level of acidity within the tumour. (c) 2005 Elsevier Ltd. All rights reserved.