Relation of anemia to low heart rate variability in patients with coronary heart disease (from the Heart and Soul study).
Relation of anemia to low heart rate variability in patients with coronary heart disease (from the Heart and Soul study).
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冠心病患者贫血与低心率变异性的关系（来自“心与灵魂”研究）。
DOI：
10.1016/j.amjcard.2005.02.017
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Whooley,MaryA
中科院分区：
文献类型：
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作者：
Gehi,Anil;Ix,Joachim;Shlipak,Michael;Pipkin,SharonS;Whooley,MaryA
我们对874例稳定型冠心病门诊患者进行了一项横断面研究，研究了贫血（血红蛋白≤12 g/dl）与24小时动态心电图测量的6项心率变异性（HRV）指标之间的关系。在90名患有贫血的参与者中，29%至41%的HRV较低，定义为每个HRV指数的最低四分位数，而784名没有贫血的参与者中，这一比例为23%至25%（除高频功率外，所有HRV指数的比较p值均<0.05）。除高频功率外，血红蛋白每降低1 g/dl与低心率变异性的几率增加相关。在调整了潜在的混杂变量（包括缺血、左心室质量、左心室射血分数和舒张功能障碍）后，这种相关性仍然很强。因此，贫血与稳定型冠心病患者的低HRV相关。低HRV可能介导贫血与心脏风险增加的相关性。
We examined the association between anemia (hemoglobin ≤12 g/dl) and 6 indexes of heart rate variability (HRV) as measured by 24-hour ambulatory electrocardiography in a cross-sectional study of 874 outpatients who had stable coronary heart disease. Of 90 participants who had anemia, 29% to 41% had low HRV, defined as the lowest quartile of each HRV index, compared with 23% to 25% of the 784 participants who did not have anemia (comparison p values <0.05 for all HRV indexes except high-frequency power). With the exception of high-frequency power, each 1 g/dl decrease in hemoglobin was associated with increased odds of having low HRV. This association remained strong after adjustment for potential confounding variables, including ischemia, left ventricular mass, left ventricular ejection fraction, and diastolic dysfunction. Thus, anemia is associated with low HRV in ambulatory patients who have stable coronary heart disease. Low HRV could potentially mediate the association of anemia with increased cardiac risk.