ENHANCEMENT BY COCAINE OF INTRA-CRANIAL SELF-STIMULATION IN RAT
ENHANCEMENT BY COCAINE OF INTRA-CRANIAL SELF-STIMULATION IN RAT
复制标题
DOI：
10.1016/0024-3205(70)90190-6
复制
发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
CROW, TJ
中科院分区：
文献类型：
--
作者：
CROW, TJ
Male hooded rats implanted with bipolar electrodes in the ventral midbrain tegmentum were injected with either cocaine hydrochloride or saline ip to determine if cocaine can by itself enhance self-stimulation rates as amphetamines have been shown to do. It was found that 5 mg/kg cocaine produced enhancement of response rate similar to that of the amphetamines. It is suggested that these results can be considered to be consistent with the aminergic theory of reward, whereby these drugs act by a sensitization of the reward system by blockade of uptake or by increasing the amount of transmitter released by nerve activity, only if it can be shown that these drugs potentiate the effect of neural release of catecholamines.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
