Triple-negative breast cancer and the potential for targeted therapy.
Triple-negative breast cancer and the potential for targeted therapy.
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DOI：
10.2217/pgs-2017-0117
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发表时间：
2017-11
期刊：
影响因子：
2.1
通讯作者：
Andrechek ER
中科院分区：
文献类型：
--
作者：
Jhan JR;Andrechek ER
乳腺癌由雌激素受体、孕激素受体和HER2三阴性乳腺癌(TNBC)等几种公认的亚型组成。在没有可用的靶向治疗选择的情况下，TNBC的标准护理仍然是化疗。值得注意的是，与其他亚型相比，TNBC肿瘤对化疗的反应通常更好。然而，无完全应答的患者约占TNBC的80%。越来越多的证据表明，TNBC亚型具有显著的异质性，研究集中在高表达变异率的遗传靶点上。最近的研究表明，在TNBC中靶向治疗可能带来明显的益处。在这篇综述中，我们总结了靶向治疗的研究，包括在小鼠模型内的研究，并讨论了它们在开发联合治疗TNBC方面的应用。
Breast cancer is composed of several well-recognized subtypes including estrogen receptor, progesterone receptor and HER2 triple-negative breast cancer (TNBC). Without available targeted therapy options, standard of care for TNBC remains chemotherapy. It is of interest to note that TNBC tumors generally have better responses to chemotherapy compared with other subtypes. However, patients without complete response account for approximately 80% of TNBC. Mounting evidence suggests significant heterogeneity within the TNBC subtype, and studies have focused on genetic targets with high rates of altered expression. Recent studies suggest clear possibilities for benefits from targeted therapy in TNBC. In this review, we summarize studies of targeted therapy, including within mouse models, and discuss their applications in the development of combinatorial treatments to treat TNBC.
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影响因子：
8
作者：
通讯作者：
--
DOI：
10.1158/1078-0432.ccr-16-2174
发表时间：
2017-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Afghahi A;Timms KM;Vinayak S;Jensen KC;Kurian AW;Carlson RW;Chang PJ;Schackmann E;Hartman AR;Ford JM;Telli ML
通讯作者：
Telli ML
影响因子：
50.3
作者：
Castel P;Ellis H;Bago R;Toska E;Razavi P;Carmona FJ;Kannan S;Verma CS;Dickler M;Chandarlapaty S;Brogi E;Alessi DR;Baselga J;Scaltriti M
通讯作者：
Scaltriti M
影响因子：
64.8
作者：
Curtis, Christina;Shah, Sohrab P.;Chin, Suet-Feung;Turashvili, Gulisa;Rueda, Oscar M.;Dunning, Mark J.;Speed, Doug;Lynch, Andy G.;Samarajiwa, Shamith;Yuan, Yinyin;Graef, Stefan;Ha, Gavin;Haffari, Gholamreza;Bashashati, Ali;Russell, Roslin;McKinney, Steven;Langerod, Anita;Green, Andrew;Provenzano, Elena;Wishart, Gordon;Pinder, Sarah;Watson, Peter;Markowetz, Florian;Murphy, Leigh;Ellis, Ian;Purushotham, Arnie;Borresen-Dale, Anne-Lise;Brenton, James D.;Tavare, Simon;Caldas, Carlos;Aparicio, Samuel
通讯作者：
Aparicio, Samuel
影响因子：
4.6
作者：
Dai M;Zhang C;Ali A;Hong X;Tian J;Lo C;Fils-Aimé N;Burgos SA;Ali S;Lebrun JJ
通讯作者：
Lebrun JJ