REM deprivation but not sleep fragmentation produces a sex-specific impairment in extinction
REM deprivation but not sleep fragmentation produces a sex-specific impairment in extinction
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DOI：
10.1016/j.physbeh.2018.08.008
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发表时间：
2018-11-01
影响因子：
2.9
通讯作者：
Hunter, Amy Silvestri
中科院分区：
文献类型：
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作者：
Hunter, Amy Silvestri
快速眼动睡眠对于学习和记忆过程，尤其是情绪学习至关重要。快速眼动睡眠的操纵会损害学习和记忆，并且睡眠结构通常会在学习经历后发生改变；例如，在恐惧调节后立即进行短期快速眼动睡眠剥夺会导致消退受损。鉴于研究表明恐惧调节存在性别依赖性差异以及睡眠结构差异，本研究调查了短期快速眼动剥夺对雄性和雌性大鼠条件性恐惧消失的影响。此外，有证据表明，快速眼动睡眠剥夺导致的睡眠碎片化会对学习和记忆产生负面影响，因此将这种操作与快速眼动睡眠剥夺和对照条件进行了比较。将雄性和雌性大鼠置于恐惧调节条件下，然后进行 6 小时的 REM 剥夺、睡眠碎片化或对照条件。调节后每隔 48 小时进行两次消退过程。快速眼动睡眠剥夺，但不是睡眠碎片或控制条件，条件性恐惧的消退受损。然而，这种效应仅在雄性大鼠中出现。这项研究首次探讨了睡眠控制对雌性大鼠记忆力的影响，并表明雌性大鼠对快速眼动睡眠剥夺的有害影响更具抵抗力。此外，它还表明，快速眼动睡眠剥夺而不是睡眠碎片化会损害条件性恐惧的消除。
REM sleep is essential for learning and memory processes, particularly emotional learning. Manipulations of REM sleep impair learning and memory and sleep architecture is often altered following a learning experience; for example, short term REM deprivation immediately after fear conditioning results in impaired extinction. In light of research demonstrating sex-dependent differences in fear conditioning as well as differences in sleep architecture, the present study investigated the effects of short term REM deprivation on the extinction of conditioned fear in male and female rats. In addition, given evidence that sleep fragmentation, which is a consequence of REM deprivation, can negatively impact learning and memory, this manipulation was compared to REM deprivation and a control condition. Male and female rats were exposed to fear conditioning followed by 6 h of REM deprivation, sleep fragmentation, or a control condition. Two extinction sessions were conducted at 48 h intervals after conditioning. REM deprivation, but not sleep fragmentation or the control condition, impaired extinction of conditioned fear. However, this effect was seen only in male rats. This study is the first to explore the effects of sleep manipulations on memory in female rats and suggests that female rats are more resilient to the deleterious effects of REM deprivation. In addition, it demonstrates that REM deprivation but not fragmentation of sleep is responsible for impairment in extinction of conditioned fear.