Flexible Coordinator and Switcher Hubs for Adaptive Task Control
Flexible Coordinator and Switcher Hubs for Adaptive Task Control
复制标题
DOI：
10.1523/jneurosci.2559-19.2020
复制
发表时间：
2020-09-02
影响因子：
5.3
通讯作者：
Cole, Michael W.
中科院分区：
文献类型：
--
作者：
Cocuzza, Carrisa, V;Ito, Takuya;Cole, Michael W.
功能连接性(Function Connection，FC)研究发现，至少有两个大型神经系统构成认知控制网络，即额顶顶神经网络(FPN)和扣带盖神经网络(CON)。控制网络被认为支持目标导向的认知和行为。以前的研究表明，FPN可以根据任务目标灵活地改变其全局连接模式，这与认知控制的“灵活中枢”机制一致。我们的目标是在这一发现的基础上，根据动态网络属性开发控制网络的功能制图(多参数剖面图)。我们使用高控制需求认知范式量化了人类(男性和女性)的网络属性，该范式涉及任务集之间的切换。我们假设，认知控制是由FPN和CON通过网络动力学中反映的不同但互补的角色来实施的。与灵活的“协调员”机制相一致的是，在保持网络内连通性以协助跨区域协调的同时，各任务之间的FPN连接是不同的。与灵活的“切换”机制相一致，CON区域以依赖于任务的方式切换到其他网络，主要是通过减少到其他CON区域的网络内连接来驱动的。这种结果模式表明，FPN充当与目标相关的信息的动态、全球协调者，而CON则暂时解散，将处理资源借给其他与目标相关的网络。这张网络动态图揭示了两个重要的认知控制网络之间的分离，暗示了目标导向认知背后的互补机制。
Functional connectivity (FC) studies have identified at least two large-scale neural systems that constitute cognitive control networks, the frontoparietal network (FPN) and cingulo-opercular network (CON). Control networks are thought to support goal-directed cognition and behavior. It was previously shown that the FPN flexibly shifts its global connectivity pattern according to task goal, consistent with a "flexible hub" mechanism for cognitive control. Our aim was to build on this finding to develop a functional cartography (a multimetric profile) of control networks in terms of dynamic network properties. We quantified network properties in (male and female) humans using a high-control-demand cognitive paradigm involving switching among 64 task sets. We hypothesized that cognitive control is enacted by the FPN and CON via distinct but complementary roles reflected in network dynamics. Consistent with a flexible "coordinator" mechanism, FPN connections were varied across tasks, while maintaining within-network connectivity to aid cross-region coordination. Consistent with a flexible "switcher" mechanism, CON regions switched to other networks in a task-dependent manner, driven primarily by reduced within-network connections to other CON regions. This pattern of results suggests FPN acts as a dynamic, global coordinator of goal-relevant information, while CON transiently disbands to lend processing resources to other goal-relevant networks. This cartography of network dynamics reveals a dissociation between two prominent cognitive control networks, suggesting complementary mechanisms underlying goal-directed cognition.