STRUCTURAL ALTERATION OF THE MEMBRANE OF ERYTHROCYTES INFECTED WITH BABESIA-BOVIS
STRUCTURAL ALTERATION OF THE MEMBRANE OF ERYTHROCYTES INFECTED WITH BABESIA-BOVIS
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DOI：
10.4269/ajtmh.1985.34.45
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发表时间：
1985-01-01
影响因子：
3.3
通讯作者：
MILLER, LH
中科院分区：
文献类型：
--
作者：
AIKAWA, M;RABBEGE, J;MILLER, LH
牛B.牛，牛巴贝斯虫病的病原体，诱导受感染红细胞膜的特征性改变。椭圆形突出物，测量约。320纳米和。160 nm出现在感染红细胞的膜上，在体外和体内都有。冻裂显示膜内颗粒（IMP）沿着突起的P面（原生质面）和E面（内质面）的长轴排列。内质面IMP的数量增加，但突起原质面IMP的数量与未感染红细胞的数量没有统计学上的变化。在体外实验中，每个感染牛b型毒株（低传代型）的红细胞比感染牛b型毒株（高传代型）的红细胞有更多的突起。在受感染的红细胞膜上出现的突起的数量可能与寄生虫的毒力有直接关系。这些突出物可能附着在毛细血管内皮细胞上，引起致命的脑巴贝斯虫病。
B. bovis, causative agent of cattle babesiosis, induces characteristic alterations on the membrane of infected erythrocytes. Elliptical protrusions measuring .apprx. 320 nm and .apprx. 160 nm appear on the membrane of infected erythrocytes, both in vitro and in vivo. Freeze-fracture demonstrated alignment of intramembrane particles (IMP) along the long axis of both the P[protoplasmic] and E[endoplasmic] faces of the protrusions. The number of IMP on the endoplasmic face increases, but the number of IMP on the protoplasmic face of the protrusions is not statistically altered from that of uninfected erythrocytes. In vitro, there are more protrusions per erythrocyte infected with the virulent form (low passage form) of b. bovis than with the avirulent form (high passage form). The number of protrusions which appear on the membrane of infected rrythrocytes may have a direct relationship to the virulence of the parasites. These protrusions may be attached to the capillary endothelial cells, which causes fatal cerebral babesiosis.