SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer
SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer
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DOI：
10.1007/s11604-016-0531-9
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发表时间：
2016-05-01
影响因子：
2.1
通讯作者：
Hirota, Shozo
中科院分区：
文献类型：
--
作者：
Doi, Hiroshi;Kitajima, Kazuhiro;Hirota, Shozo
我们的目的是确定[F-18]-氟-2-脱氧葡萄糖正电子发射断层扫描/计算机断层扫描显示的原发性病变的最大标准化摄取值（SUVmax）是否FDG-PET/CT显像与上颌窦癌的预后有关，探讨年龄、T分期、N分期、组织学类型、治疗策略、采用log-rank检验和考克斯方法对31例上颌窦癌患者在接受大剂量顺铂超选择动脉化疗联合放疗前的原发肿瘤SUVmax、无进展生存期（PFS）和总生存期（OS）进行评估，中位随访时间为55.4（9.7-72.6）个月。原发性肿瘤SUVmax较高（分别为千分之一日元16和千分之一日元17）的患者的PFS和OS显著低于原发性肿瘤SUVmax较低的患者（分别为p = 0.0010和p = 0.033）。多因素分析显示T分期（p = 0.0049）和原发肿瘤SUVmax（p = 0.026）是PFS较差的独立预后因素，只有原发肿瘤SUVmax（p = 0.049）是OS较差的独立预后因素，治疗前FDG-PET/CT测定的原发肿瘤SUVmax可作为上颌窦癌预后的良好替代指标。
Our aim was to determine whether the maximum standardized uptake value (SUVmax) of the primary lesion demonstrated by [F-18]-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is associated with the prognosis of maxillary sinus cancer.The relationships of clinicopathological factors including age, T stage, N stage, histologic type, treatment strategy, and primary tumor SUVmax with progression-free (PFS) and overall (OS) survival were evaluated using the log-rank test and Cox method in 31 patients with maxillary sinus cancer before combined superselective intra-arterial chemotherapy using high-dose cisplatin with concurrent radiotherapy, or radiotherapy alone.The median duration of follow-up was 55.4 (range 9.7-72.6) months. PFS and OS of patients exhibiting a high SUVmax (a parts per thousand yen16 and a parts per thousand yen17, respectively) for the primary tumor were significantly lower than those of patients for whom the primary tumor SUVmax was low (p = 0.0010 and p = 0.033, respectively). Multivariate analyses showed that T stage (p = 0.0049) and primary tumor SUVmax (p = 0.026) were independently prognostic of poorer PFS and that only primary tumor SUVmax (p = 0.049) was independently prognostic of poorer OS.SUVmax of the primary tumor determined by FDG-PET/CT before treatment could be a good surrogate marker for prognostication of maxillary sinus cancer.