Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau
Hydrophobic tagging-mediated degradation of Alzheimer's disease related Tau
复制标题
疏水标签介导的阿尔茨海默病相关 Tau 蛋白降解
DOI：
10.1039/c7ra05347a
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发表时间：
2017-01-01
期刊：
影响因子：
3.9
通讯作者：
Li, Yan-Mei
中科院分区：
文献类型：
--
作者：
Gao, Na;Chu, Ting-Ting;Li, Yan-Mei
Tau降低是治疗阿尔茨海默病（AD）的有利策略。本研究设计并合成了一种疏水标签结合肽（HyT-Tau-CPP），用于选择性地促进Tau的降解。HyT-Tau-CPP可有效降低Tau水平，并呈浓度和时间依赖性。此外，HyT-Tau-CPP还能降低AD模型小鼠脑内Tau蛋白的水平。因此，HyT-Tau-CPP降低Tau可能成为治疗AD的潜在治疗策略。
Tau reduction is a favorable strategy for Alzheimer's disease (AD) treatment. In this work, we designed and synthesized a hydrophobic tag conjugated peptide (HyT-Tau-CPP) to selectively promote the degradation of Tau. HyT-Tau-CPP could potently lower the Tau level in a concentration-and time-dependent manner. Furthermore, HyT-Tau-CPP could also reduce the level of Tau in the brain of AD mouse models. Therefore, Tau reduction by HyT-Tau-CPP may become a potential therapeutic strategy in the treatment for AD.