Brain atrophy in alcoholics:: Relationship with alcohol intake;: Liver disease;: Nutritional status, and inflammation
Brain atrophy in alcoholics:: Relationship with alcohol intake;: Liver disease;: Nutritional status, and inflammation
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DOI：
10.1093/alcalc/agm065
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发表时间：
2007-11-01
影响因子：
2.8
通讯作者：
Rodriguez-Rodriguez, Eva
中科院分区：
文献类型：
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作者：
Garcia-Valdecasas-Campelo, Elena;Gonzalez-Reimers, Emilio;Rodriguez-Rodriguez, Eva
目的：脑萎缩是酗酒者的常见表现。可能涉及几种机制，包括乙醇本身、营养不良、肝功能衰竭，以及可能的乙醇诱导的激素和细胞因子变化。本研究的目的是分析通过计算机断层扫描（CT）评估的脑萎缩与上述改变的关系。研究方法：对36名酗酒者（其中10名为酒精中毒者）进行了血清胰岛素样生长因子1（IGF-1）、白细胞介素（IL）-6、IL-8、IL-10、TNF α、PTH、雌二醇、游离睾酮和皮质酮测定，这些酗酒者还接受了脑CT检查，记录了皮质萎缩或小脑萎缩、Evans、Huckmanns、切拉细胞、双尾状核、皮质萎缩、双额叶和心室指数，和第三脑室的直径;主观营养评估、上臂人体测量和肝功能评价。结果如下：与12名对照组相比，患者的所有CT指标均显示出显著变化，但这些指标与分析的其他参数（IGF-1、握力和成瘾年限与双额指数（所有病例均为P 0.025）; PTH和Evans指数（r=0.36，P=0.032）;平均红细胞体积与切拉指数和皮质萎缩（P 0.05））之间的相关性较差。小脑萎缩与每日乙醇消耗量增加相关（t=2.19，P=0.034）。结论：酗酒者经常出现脑萎缩，但与肝功能、细胞因子、营养状况和激素水平的关系不佳。
Objectives: Brain atrophy is a common finding in alcoholics. Several mechanisms may be involved, including ethanol itself, malnutrition, liver failure, and, possibly, ethanol-induced hormone and cytokine changes. The aim of this study was to analyse the relation of brain atrophyassessed by computerized tomography (CT) scanand the aforementioned alterations. Methods: Serum insulin-like growth factor 1 (IGF-1), interleukin (IL)-6, IL-8, IL-10, TNF alpha, PTH, estradiol, free testosterone, and corticosterone were measured in 36 alcoholics, ten of them cirrhotics, who also underwent brain CT, which recorded the presence of cortical atrophy or cerebellar atrophy, Evans, Huckmanns, cella media, bicaudate, cortical atrophy, bifrontal, and ventricular indices, and diameter of the third ventricle; subjective nutritional assessment, midarm anthropometry, and evaluation of liver function. Results: Patients showed marked alterations of all the CT indices compared with 12 controls, but poor relations between these indices and the other parameters analysed (IGF-1, handgrip strength and years of addiction with bifrontal index (P0.025 in all cases); PTH and Evans index (r=0.36, P=0.032); mean corpuscular volume with cella index and cortical atrophy (P0.05). Cerebellar atrophy was associated with a greater daily ethanol consumption (t=2.19, P=0.034). Conclusion: Brain atrophy is frequently observed in alcoholics, but relationships with liver function, cytokines, nutritional status, and hormone levels are poor.