A tidal ventilation model for oxygenation in respiratory failure
A tidal ventilation model for oxygenation in respiratory failure
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DOI：
10.1016/s1569-9048(03)00066-1
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发表时间：
2003-06-12
影响因子：
2.3
通讯作者：
Hahn, CEW
中科院分区：
文献类型：
--
作者：
Whiteley, JP;Farmery, AD;Hahn, CEW
我们开发了潮汐通气肺气体交换方程，该方程允许肺分流在呼气和吸气期间具有不同的值，与肺功能障碍期间的肺萎陷和复张一致[Am.呼吸杂志。158（1998）1636]。他们的解决方案是根据血管内氧张力和饱和度传感器公布的动物数据进行测试的。这些方程为（i）观察到的生理现象提供了一种解释，例如动脉氧饱和度和血气张力的呼吸内波动;以及（ii）常规（时间平均）血气样本氧张力。我们建议，潮式通气模型，需要描述呼吸内波动的动脉血氧饱和度和血气张力在急性呼吸窘迫综合征（ARDS）的主题。这些氧饱和度和张力波动的幅度以及平均氧血气值都受到生理变量的影响，例如吸入氧浓度、肺容量和吸气：呼气（LE）比，以及呼吸周期期间肺分流的变化。(C)2003 Elsevier Science B. V.保留所有权利。
We develop tidal-ventilation pulmonary gas-exchange equations that allow pulmonary shunt to have different values during expiration and inspiration, in accordance with lung collapse and recruitment during lung dysfunction [Am. J. Respir. Crit. Care Med. 158 (1998) 1636]. Their solutions are tested against published animal data from intravascular oxygen tension and saturation sensors. These equations provide one explanation for (i) observed physiological phenomena, such as within-breath fluctuations in arterial oxygen saturation and blood-gas tension; and (ii) conventional (time averaged) blood-gas sample oxygen tensions. We suggest that tidal-ventilation models are needed to describe within-breath fluctuations in arterial oxygen saturation and blood-gas tension in acute respiratory distress syndrome (ARDS) subjects. Both the amplitude of these oxygen saturation and tension fluctuations, and the mean oxygen blood-gas values, are affected by physiological variables such as inspired oxygen concentration, lung volume, and the inspiratory:expiratory (LE) ratio, as well as by changes in pulmonary shunt during the respiratory cycle. (C) 2003 Elsevier Science B.V. All rights reserved.