Ketamine Modulates Theta and Gamma Oscillations
Ketamine Modulates Theta and Gamma Oscillations
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DOI：
10.1162/jocn.2009.21305
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发表时间：
2010-07-01
影响因子：
3.2
通讯作者：
Siegel, Steven J.
中科院分区：
文献类型：
--
作者：
Lazarewicz, Maciej T.;Ehrlichman, Richard S.;Siegel, Steven J.
氯胺酮是一种N-甲基-D-天冬氨酸（NMDA）受体激动剂，已被研究为亚麻醉剂量时精神分裂症的模型。在EEG研究中，氯胺酮以复杂的方式影响感觉门控并改变神经元信号的振荡特性。我们研究了氯胺酮对在体记录从小鼠海马CA 3区参考同侧额窦使用成对点击听觉门控范例的影响。一个特别感兴趣的问题是阐明氯胺酮对背景网络活动，刺激后诱发和诱导活动的影响。我们发现，氯胺酮衰减θ频带的背景活动和刺激后诱发活动。氯胺酮也破坏了后期，刺激后θ波功率降低控制记录。在伽马频率范围内，氯胺酮增强背景和诱发功率，但降低相对诱导功率。这些发现支持NMDA受体的作用，inmediating之间的平衡θ和γ反应的感觉刺激，与精神分裂症的功能障碍可能的影响。
Ketamine, an N-methyl-D-aspartate (NMDA) receptor glutamatergic antagonist, has been studied as a model of schizophrenia when applied in subanesthetic doses. In EEG studies, ketamine affects sensory gating and alters the oscillatory characteristics of neuronal signals in a complex manner. We investigated the effects of ketamine on in vivo recordings from the CA3 region of mouse hippocampus referenced to the ipsilateral frontal sinus using a paired-click auditory gating paradigm. One issue of particular interest was elucidating the effect of ketamine on background net-work activity, poststimulus evoked and induced activity. We find that ketamine attenuates the theta frequency band in both background activity and in poststimulus evoked activity. Ketamine also disrupts a late, poststimulus theta power reduction seen in control recordings. In the gamma frequency range, ketamine enhances both background and evoked power, but decreases relative induced power. These findings support a role for NMDA receptors inmediating the balance between theta and gamma responses to sensory stimuli, with possible implications for dysfunction in schizophrenia.