No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years
No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years
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DOI：
10.1017/s000711451100403x
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发表时间：
2012-04-01
影响因子：
3.6
通讯作者：
Kennedy, David O.
中科院分区：
文献类型：
--
作者：
Jackson, Philippa A.;Deary, Michael E.;Kennedy, David O.
N-3多不饱和脂肪酸是一种独特的脂肪酸，不能由身体制造，必须通过饮食来源获得。在英国和其他西方国家，这些“必需”脂肪酸的消耗量低于政府的指导方针。以159名18~35岁健康青年为研究对象，研究了两种鱼油(富含DHA鱼油和富含EPA鱼油)在膳食中添加1g/d 12周的效果。在为期12周的治疗方案前后，对一系列计算机化认知任务和情绪测量的表现进行了评估。参与者在两个时间点也提供了静脉血液样本，随后分析了血清脂肪酸浓度。尽管与安慰剂相比，研究方案依从性很好--反映在n-3血清脂肪酸浓度的增加上--但观察到的两种有效治疗的效果都很小。唯一值得注意的发现是，补充富含EPA的FO可能会在认知需求较高的时候减少主观精神疲劳，尽管还需要进一步的研究。这些发现与其他最近关于无效效果的报告一起表明，在健康、正常发育和无损伤的人群中补充n-3多不饱和脂肪酸不太可能导致认知增强。
The n-3 PUFA are a unique class of fatty acids that cannot be manufactured by the body, and must be acquired via dietary sources. In the UK, as well as in other Western nations, these 'essential' fatty acids are consumed in quantities that fall below government guidelines. The present study explored the effects of 12 weeks' dietary supplementation with 1 g/d of two types of fish oil (FO; DHA-rich and EPA-rich) in 159 healthy young adults aged 18-35 years. An assessment of performance on a battery of computerised cognitive tasks and mood measures took place before and following the 12-week treatment regimen. Venous blood samples were also supplied by participants at both time points which were later analysed for serum fatty acid concentrations. Despite good adherence to the study protocol - as reflected in increased concentrations of n-3 serum fatty acids - compared with placebo, the observed effects of both active treatments were minimal. The only finding of note revealed that supplementation with EPA-rich FO may reduce subjective mental fatigue at times of high cognitive demand, although further investigation is required. These findings, taken together with other recent reports of null effects, suggest that dietary supplementation with n-3 PUFA in healthy, normally developing and impairment-free populations is unlikely to result in cognitive enhancement.