DUPLICATION, DELETION, AND POLYMORPHISM IN THE SEX-DETERMINING REGION OF THE MOUSE Y-CHROMOSOME
DUPLICATION, DELETION, AND POLYMORPHISM IN THE SEX-DETERMINING REGION OF THE MOUSE Y-CHROMOSOME
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DOI：
10.1126/science.2563173
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发表时间：
1989-01-06
期刊：
影响因子：
56.9
通讯作者：
PAGE, DC
中科院分区：
文献类型：
--
作者：
MARDON, G;MOSHER, R;PAGE, DC
人类Y染色体性别决定区的ZFY基因编码一种“锌指”蛋白，可能是睾丸决定因子TDF。虽然大多数胎盘哺乳动物的Y染色体携带ZFY的单一同源物，但小鼠的Y染色体有两个同源物，都在性别决定（Sxr）区域。Zfy-1可能足以决定雄性; Zfy-2是缺失的，因为它在Sxr变体中被删除，保留了性别决定功能，但失去了其他基因。这两个位点都定位在小鼠Y染色体的着丝粒附近。本文报道了小家鼠（Mus musculus）和小家鼠（M. M. Zfy-1限制性片段多态性，这可以用来研究它们与常染色体性别决定基因的不同相互作用。
The ZFY gene in the sex-determining region of the human Y chromosome encodes a "zinc-finger" protein that may be the testis-determining factor, TDF. Although the Y chromosomes of most placental mammals carry a single homolog of ZFY, the mouse Y chromosome has two homologs, both in the sex-determining (Sxr) region. Zfy-1 alone may suffice to determine maleness; Zfy-2 is dispensable, as it was deleted in an Sxr variant that retains sex-determining function but has lost other genes. Both loci mapped near the centromere of the mouse Y chromosome. The Y chromosomes of the subspecies Mus musculus and M. m. domesticus were distinguishable by a Zfy-1 restriction fragment polymorphism, which can be used to study their differing interactions with autosomal sex-determining genes.