An Evaluation of the Effects of Methylphenidate on Outcomes in Adult Epilepsy Patients
An Evaluation of the Effects of Methylphenidate on Outcomes in Adult Epilepsy Patients
复制标题
哌醋甲酯对成人癫痫患者预后影响的评估
DOI：
10.1006/ebeh.2001.0313
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发表时间：
2002
影响因子：
2.6
通讯作者：
R. Bornstein
中科院分区：
文献类型：
--
作者：
J. Moore;J. McAuley;L. Long;R. Bornstein
目的。为了确定哌醋甲酯(MPH)治疗是否能改善成年癫痫患者对多种抗癫痫药物(AEDs)的认知，我们评估了MPH对初诊为定位相关癫痫患者的癫痫发作活动、生活质量、认知和疲劳的影响。这是一项为期3个月的开放标签、非随机研究。在患者目前的抗癫痫药物方案中加入了PMH(利他林)。观察指标包括癫痫发作活动度、选定的AED血清浓度、生活质量(通过癫痫患者的生活质量-89问卷(QOLIE-89))、认知(通过Microcog)和疲劳(通过视觉模拟量表)。11名患者入选，8名患者完成了这项初步研究。在完成研究的8人中，有5人在基线和整个研究过程中没有癫痫发作。1例患者癫痫发作活动增加，1例减少，1例无变化。未观察到严重不良反应。平均而言，从基线到研究结束，血清AED浓度变化了10%。QOLIE-89总分和部分领域的平均得分较基线有显著改善。所有的Microcog结构域都比基线有所改善。疲劳程度也有明显改善。成年癫痫患者使用mph镇静后得到缓解，生活质量得到改善，发作控制没有明显改变。
Purpose. To determine if methylphenidate (MPH) therapy can improve cognition in adult epilepsy patients on multiple antiepileptic drugs (AEDs), we assessed the impact of MPH on seizure activity, quality of life, cognition, and fatigue in patients with a primary diagnosis of localization-related epilepsy.Methods. This was an open-label, nonrandomized 3-month study. MPH (Ritalin) was added to patients' current antiepileptic drug regimens. Outcome measures included seizure activity, select AED serum concentrations, quality of life (via Quality of Life in Epilepsy-89 questions (QOLIE-89)), cognition (via Microcog), and fatigue (via a visual analog scale) at baseline and at monthly intervals for the treatment phase.Results. Eleven patients were enrolled and eight completed this pilot study. Of the eight completing the study, five were seizure-free at baseline and throughout the study. One patient had an increase, one a decrease, and one no change in seizure activity. No serious adverse events were observed. On average, serum AED concentrations changed <10% from baseline to the end of the study. Mean overall QOLIE-89 scores and select domains improved significantly from baseline. All Microcog domains improved from baseline. Fatigue also improved significantly.Conclusions. Adult epilepsy patients received relief from sedation with MPH and showed an improved quality of life, without significant alteration of seizure control.