Mechanical properties and degradation of drug eluted bioresorbable vascular scaffolds prepared by three-dimensional printing technology
Mechanical properties and degradation of drug eluted bioresorbable vascular scaffolds prepared by three-dimensional printing technology
复制标题
三维打印技术制备药物洗脱生物可吸收血管支架的力学性能及降解
DOI：
10.1080/09205063.2019.1586303
复制
发表时间：
2019-05-03
影响因子：
3.6
通讯作者：
Zhou, Min
中科院分区：
文献类型：
--
作者：
Zhang, Yepeng;Zhao, Jie;Zhou, Min
生物可吸收血管支架有望取代传统的金属支架，避免金属支架的长期并发症。然而，传统的支架制造工艺很难满足血管病变个体化治疗的要求，需要不同的形态。在此，我们采用了一种新的支架制造方法——三维打印技术，制备了生物可吸收血管支架。制备的支架以西罗莫司与支架制备材料混合负载，缓释药物。对工程化的、载药的、生物可吸收的血管支架（BVS）进行了体内分析和试验。三维打印技术制备的支架具有良好的力学性能和体外降解性能。结果还表明，这些支架在药物长期降解和缓释后仍能保持有效的径向强度。作为一种新的支架制备方法，它可能为生物可吸收血管支架技术的发展提供了一个很好的思路。
Abstract Bioresorbable vascular scaffolds are expected to replace the traditional metal stent, avoiding the long-term complications of metal stents. However, it is hard for the traditional scaffold manufacturing process to meet the requirements of individualized treatment for vascular lesions, which requires different morphologies. Here, we used a new method of scaffold manufacturing, three-dimensional printing technology, to prepare bioresorbable vascular scaffolds. The fabricated scaffold was loaded with sirolimus mixed with scaffold preparation material for slow drug release. The engineered, drug- loaded, bioresorbable vascular scaffold (BVS) was analyzed and tested in vivo. The scaffolds produced by three-dimensional printing technology exhibited good mechanical properties and in vitro degradation performance. The results also suggested that these scaffolds could maintain effective radial strength after long-term degradation and sustained release of the drug. As a new scaffold preparation method, it may provide a promising idea for developing bioresorbable vascular scaffold technology.