Magnetic-sensitive behavior of intelligent ferrogels for controlled release of drug
Magnetic-sensitive behavior of intelligent ferrogels for controlled release of drug
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DOI：
10.1021/la060371e
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发表时间：
2006-07-04
期刊：
影响因子：
3.9
通讯作者：
Chen, San-Yuan
中科院分区：
文献类型：
--
作者：
Liu, Ting-Yu;Hu, Shang-Hsiu;Chen, San-Yuan
将聚乙烯醇（PVA）水凝胶与Fe3O4磁性颗粒通过冻融循环混合制备智能磁性水凝胶（铁凝胶）。虽然对铁凝胶施加外部直流磁场，药物在铁凝胶周围积聚，但当磁场瞬间“关闭”时，积聚的药物瞬间喷射到环境中。此外，当磁场从“关”模式切换到“开”模式时，可以快速或缓慢地调节药物释放。在一定的磁场条件下，铁凝胶的药物释放行为主要受Fe3O4颗粒大小的影响。Fe3O4颗粒越大，其饱和磁化强度越强，矫顽力越小，铁凝胶的“磁敏效应”越好。此外，药物释放量可以通过在给定磁场中通过外部可控的开关操作来微调开关持续时间（SDT）来控制。结果表明，在SDT时间为10 min和5 min时，铁凝胶的爆发药物量最高，结构最接近。通过利用目前合成的新型铁凝胶的这些特殊的磁敏特性，人们高度期望它具有可控制或可编程的药物释放特征，可以设计用于实际临床需求。
An intelligent magnetic hydrogel (ferrogel) was fabricated by mixing poly(vinyl alcohol) (PVA) hydrogels and Fe3O4 magnetic particles through freezing-thawing cycles. Although the external direct current magnetic field was applied to the ferrogel, the drug was accumulated around the ferrogel, but the accumulated drug was spurt to the environment instantly when the magnetic fields instantly switched "off". Furthermore, rapid to slow drug release can be tunable while the magnetic field was switched from "off" to "on" mode. The drug release behavior from the ferrogel is strongly dominated by the particle size of Fe3O4 under a given magnetic field. The best "magnetic-sensitive effects" are observed for the ferrogels with larger Fe3O4 particles due to its stronger saturation magnetization and smaller coercive force. Furthermore, the amount of drug release can be controlled by fine-tuning of the switching duration time (SDT) through an externally controllable on-off operation in a given magnetic field. It was demonstrated that the highest burst drug amounts and best "close" configuration of the ferrogel were observed for the SDT of 10 and 5 min, respectively. By taking these peculiar magnetic-sensitive characteristics of the novel ferrogels currently synthesized, it is highly expected to have a controllable or programmable drug release profile that can be designed for practical clinical needs.