Immunoregulation in disseminated histoplasmosis: characterization of the surface phenotype of splenic suppressor T lymphocytes.
Immunoregulation in disseminated histoplasmosis: characterization of the surface phenotype of splenic suppressor T lymphocytes.
复制标题
播散性组织胞浆菌病的免疫调节：脾抑制 T 淋巴细胞表面表型的特征。
DOI：
10.1128/iai.37.3.940-945.1982
复制
发表时间：
1982
影响因子：
3.1
通讯作者：
Bullock,WE
中科院分区：
文献类型：
--
作者：
Watson,SR;Bullock,WE
C57BL/6 and C3H/HeJ mice were infected intravenously with 6 X 10(5) yeast-phase Histoplasma capsulatum organisms. After 1 week, splenocytes from both mouse strains showed diminished antibody responses to sheep erythrocytes in vitro; these cells also were able to suppress the response of normal syngeneic cells. Passage of splenocytes from infected mice through a nylon wool column yielded a population enriched for T cells that exerted suppressor activity, although to a smaller extent than did unfractionated cells. Treatment of the T-cell-enriched population from both strains of mice with either anti-Thy 1.2 or anti-Ly 2 and complement resulted in a loss of this immunosuppressive ability. In addition, anti-I-Jk antiserum was effective in ablating the suppressive effect of C3H/HeJ nylon wool-passed spleen cells. The conclusion drawn from these experiments is that the T cells from H. capsulatum-infected animals which are capable of modulating the in vitro plaque-forming cell response to sheep erythrocytes bear Ly 2 and I-J determinants on their surfaces.
