Graphene oxide fiber microelectrodes with controlled sheet alignment for sensitive neurotransmitter detection
Graphene oxide fiber microelectrodes with controlled sheet alignment for sensitive neurotransmitter detection
复制标题
具有受控薄片排列的氧化石墨烯纤维微电极，用于灵敏的神经递质检测
DOI：
10.1039/d3nr02879h
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发表时间：
2023
期刊：
影响因子：
6.7
通讯作者：
Ross, Ashley E.
中科院分区：
文献类型：
--
作者：
Jarosova, Romana;Ostertag, Blaise J.;Ross, Ashley E.
在这里，我们合成并表征了具有可控纳米片取向的氧化石墨烯（GO）纤维微电极，以研究片排列和取向对神经化学物质电化学检测的影响程度。 GO 纳米片的排列通过扫描电子显微镜、拉曼光谱和循环伏安法进行表征。通过快速扫描循环伏安法（FSCV）进一步评估了GO微电极的电化学性能及其对神经递质亚秒级检测的适用性。我们已经证明，GO 片排列对电子转移动力学、频率无关行为和特定神经递质的检测适用性有相当大的影响。因此，对于基于 GO 的生物传感器的任何未来使用，都应考虑针对特定电化学检测的电极表面的微调方面。
Here, we synthesized and characterized graphene oxide (GO) fiber microelectrodes with controllable nanosheet orientation to study the extent to which sheet alignment and orientation impacts electrochemical detection of neurochemicals. The alignment of the GO nanosheets was characterized by scanning electron microscopy, Raman spectroscopy, and cyclic voltammetry. The electrochemical performance of GO microelectrodes and its suitability for subsecond detection of neurotransmitters was further evaluated by fast-scan cyclic voltammetry (FSCV). We have shown that the GO sheet alignment has a considerable effect on the electron transfer kinetics, frequency independent behavior, and detection suitability for specific neurotransmitters. Therefore, this fine-tuning aspect of the electrode surface for specific electrochemical detection should be taken into consideration for any future utilization of GO-based biological sensors.