What does flumazenil PET add to an evaluation for temporal lobectomy?
What does flumazenil PET add to an evaluation for temporal lobectomy?
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氟马西尼 PET 对颞叶切除术的评估有何帮助？
DOI：
10.1111/j.1535-7511.2005.00088.x
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发表时间：
2006
影响因子：
3.6
通讯作者：
Theodore,WilliamH
中科院分区：
文献类型：
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作者：
Theodore,WilliamH
海马硬化患者脑室周围白色物质氟马西尼结合和术后结果Hammers A，Koepp MJ，布鲁克斯DJ，邓肯JSE癫痫2005;46（6）：944- 948目的在海马硬化（HS）患者中，前颞叶切除术为三分之二的患者提供了长期抑制癫痫发作的可能性。白色物质（WM）[11 C]氟马西尼分布容积（FMZ-Vd）反映WM中神经元细胞体的数量。我们的目的是相关的WM FMZ-Vdin患者与单侧HS和postsurgical outcome.MethodsWe进行[11 C]氟马西尼正电子发射断层扫描（[11 C]FMZ-PET）在15例难治性内侧颞叶癫痫（mTLE）和定量MRI诊断单侧HS随后在所有情况下组织学验证。中位随访时间为7年（范围：6-9年）。使用代谢物校正的动脉血浆输入函数和光谱分析生成[11 C]FMZ-Vd的参数图像。统计参数映射（SPM 99）与明确的掩蔽被用来调查整个脑容量，包括WM.Results8例恩格尔IA类的结果（完全无瘤，因为手术），和7个没有无瘤。无癫痫患者与那些谁继续有癫痫发作手术后的比较显示，增加FMZ结合周围的同侧（z = 3.7）和对侧（z = 2.7）ventricles在那些次优outcomes.ConclusionsPreoperative [11 C]FMZ-PET可以检测到脑室周围的WMFMZ结合的增加，这意味着在WM异位神经元，在mTLE患者。这种增加的存在与较差的结果相关。
Periventricular White Matter Flumazenil Binding and Postoperative Outcome in Hippocampal SclerosisHammers A, Koepp MJ, Brooks DJ, Duncan JSEpilepsia2005;46(6):944–948PurposeIn patients with hippocampal sclerosis (HS), anterior temporal lobe resection offers the possibility of a long-lasting suppression of seizures in two-thirds of patients. White matter (WM) [11C]flumazenil volume of distribution (FMZ-Vd) reflects the number of neuronal cell bodies in WM. Our objective was to correlate WM FMZ-Vdin patients with unilateral HS and postsurgical outcome.MethodsWe performed [11C]flumazenil positron emission tomography ([11C]FMZ-PET) in 15 patients with refractory mesial temporal lobe epilepsy (mTLE) and a quantitative MRI diagnosis of unilateral HS subsequently histologically verified in all cases. Median follow-up was 7 years (range, 6–9 years). Metabolite-corrected arterial plasma input functions and spectral analysis were used to generate parametric images of [11C]FMZ-Vd. Statistical parametric mapping (SPM99) with explicit masking was used to investigate the entire brain volume including WM.ResultsEight patients had Engel class IA outcome (completely seizure-free since surgery), and seven were not seizure-free. Comparison of seizure-free patients with those who continued to have seizures after surgery revealed areas of increased FMZ binding around the posterior horns of the ipsilateral (z = 3.7) and contralateral (z = 2.7) ventricles in those with suboptimal outcomes.ConclusionsPreoperative [11C]FMZ-PET can detect periventricular increases of WMFMZ binding, implying heterotopic neurons in WM, in patients with mTLE. The presence of such increases correlates with a poorer outcome.
部分容量校正后，颞叶癫痫患者的 5-HT 1A 受体减少。
DOI：
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发表时间：
2005
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Giovacchini,Giampiero;Toczek,MariaT;Bonwetsch,Robert;Bagic,Anto;Lang,Lixin;Fraser,Charles;Reeves-Tyer,Pat;Herscovitch,Peter;Eckelman,WilliamC;Carson,RichardE;Theodore,WilliamH
通讯作者：
Theodore,WilliamH