An estimation of the concentration of y-aminobutyric acid and glutamate decarboxylase in the inhibitory Purkinje axon terminals in the cat.
An estimation of the concentration of y-aminobutyric acid and glutamate decarboxylase in the inhibitory Purkinje axon terminals in the cat.
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DOI：
10.1016/0006-8993(73)90038-3
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发表时间：
1973-05
期刊：
影响因子：
2.9
通讯作者：
F. Fonnum;F. Walberg
中科院分区：
文献类型：
--
作者：
F. Fonnum;F. Walberg
在本研究中，估计了浦肯野轴突终末内GABA的浓度。这些值是基于从正常和手术动物的氨基酸和酶测量、亚细胞分级和定量形态学分析中获得的数据。终扣占两个区域组织体积的4-5%，其密度估计为6-9 × 1010/cu.cm。小脑核和前庭外侧核背侧部的浦肯野轴突终末占总终末数的12-33%。GABA的浓度在50和100 mM之间; GAD的活性最多允许合成350-1000 mMGABA/h。
In the present study an estimate was made of the concentration of GABA within the Purkinje axon terminals. The values were based on data obtained from amino acid and enzyme measurements, subcellular fractionation, and quantitative morphological analyses in normal and operated animals. Boutons constituted 4–5% of the tissue volume of the two regions, and their density was estimated to be 6–9 × 1010/cu.cm. The proportion of Purkinje axon terminals within the cerebellar nuclei and the dorsal part of the lateral vestibular nucleus was 12–33% of the total bouton number. The concentration of GABA was between 50 and 100 mM; and the activity of GAD permitted, at a maximum, 350–1000 mMGABA to be synthesized/h.