Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis
Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis
复制标题
DOI：
10.1016/s0889-857x(03)00056-5
复制
发表时间：
2003-11-01
影响因子：
2.3
通讯作者：
Poole, AR
中科院分区：
文献类型：
--
作者：
Poole, AR
本文回顾了正在开发的用于检测骨关节炎 (OA) 发生和已发生的 OA 进展的新方法。这些测试主要基于生物标志物的血清或尿液测定，这些生物标志物是与关节损伤相关的特定组织特异性分子事件的产物。现在可以通过灵敏且特异性的免疫测定来检测这些生物标志物。最近对动物模型和患有膝骨关节炎的人类进行的研究表明，这些测试对于检测早期骨关节炎很有价值，并且可以区分关节损伤进展情况不同的人群。这些测定对于缓解 OA 疾病药物的临床试验也可能有价值。
This article reviews new methodologies that are being developed for the detection of incident osteoarthritis (OA) and the progression of established OA. These tests are based mainly upon serum or urine assays of biomarkers that are products of defined tissue-specific molecular events related to joint damage. These biomarkers can now be detected by sensitive and specific immunoassays. Recent studies in animal models and in humans with knee OA have revealed that these tests are of value in detecting early OA and can discriminate between populations that differ with respect to the progression of joint damage. These assays may also be of value in clinical trials of disease-modifying OA drugs.