Imprinted facultative heterochromatization in mealybugs
Imprinted facultative heterochromatization in mealybugs
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DOI：
10.1023/a:1022964700446
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发表时间：
2003-03-01
期刊：
影响因子：
1.5
通讯作者：
Prantera, G
中科院分区：
文献类型：
--
作者：
Bongiorni, S;Prantera, G
在蜡蚧科或粉蚧科中，雄性发育伴随着整个父系来源的单倍体染色体组的兼性异染色质化。这种表观遗传现象发生在卵裂中期男性胚胎的所有细胞中。因此，球虫染色体系统提供了一个强大的工具，获得洞察兼性异染色质的结构，并进入其印记，发育调控形成的表观遗传机制。本文就粉蚧的基因组印记和兼性异染色质化的研究进展作一综述。首先，DNA甲基化的存在和可能的作用，作为一种表观遗传修饰，实现了在粉蚧的印记过程的重复。本文的第二部分将集中在蛋白质参与兼性异染色质化过程。特别是，参与HP-1样蛋白质的沉默的父系来源的单倍体染色体组和其相互作用的赖氨酸9甲基化的组蛋白H3亚型将进行讨论。
In lecanoid Coccids, or mealybugs, the male development is accompanied by the facultative heterochromatization of the entire, paternally derived, haploid chromosome set. This epigenetic phenomenon occurs in all the cells of mid-cleavage male embryos. Consequently, the Coccid chromosome system offers a powerful tool for gaining insights into the structure of facultative heterochromatin, and into the epigenetic mechanisms of its imprinted, developmentally regulated formation. This paper will present new data and summarize recent studies on genomic imprinting and facultative heterochromatization in mealybugs. First, the existence and the possible role of DNA methylation as an epigenetic modification that fulfills the requisites of the imprinting process in mealybugs will be considered. The second part of this paper will focus on proteins involved in the facultative heterochromatization process. In particular, the involvement of an HP-1-like protein in the silencing of the paternally derived haploid chromosome set and its interaction with the lysine 9 methylated isoform of histone H3 will be discussed.