Low density lipoprotein particle size and risk of early-onset myocardial infarction in women
Low density lipoprotein particle size and risk of early-onset myocardial infarction in women
复制标题
DOI：
10.1093/aje/153.10.939
复制
发表时间：
2001-05-15
影响因子：
5
通讯作者：
Austin, MA
中科院分区：
文献类型：
--
作者：
Kamigaki, AS;Siscovick, DS;Austin, MA
以前对中年男性的研究表明，低密度脂蛋白（LDL）颗粒直径（大小）与冠心病之间存在单变量关联，但这种关联尚未在年轻女性中进行研究。作者使用了一项来自华盛顿州西部妇女的基于人群的病例对照研究的子样本，研究了1992-1995年LDL颗粒大小与早发性心肌梗死（MI）风险之间的关系。采用梯度凝胶电泳法对72例心肌梗死患者和159例年龄在20-44岁的对照者的非空腹血标本中的LDL亚类进行了分析。与对照组相比，病例组的平均LDL颗粒尺寸显著更小（26.4 vs. 26.9 nm，p < 0.001），LDL颗粒尺寸小1 nm的优势比为2.3（p < 0.0001）。这些结果与年龄、绝经状态、吸烟、糖尿病、高血压和LDL胆固醇无关（对于较小的LDL颗粒，比值比= 1.9-2.3，所有p < 0.02），但与体重指数、高密度脂蛋白胆固醇或甘油三酯无关（比值比分别为1.4、1.4和1.1;所有p > 0.05）。因此，在年龄校正分析中，较小的LDL颗粒大小与年轻女性的MI相关，但在校正与LDL颗粒大小和MI相关的代谢因素后，风险降低。
Previous studies of middle-aged men have shown a univariate association between low density lipoprotein (LDL) particle diameter (size) and coronary heart disease, but this association has yet to be examined in younger women. Using a subsample from a population-based case-control study of women living in western Washington State, the authors examined the association between LDL particle size and risk of early-onset myocardial infarction (MI) in 1992-1995. Gradient gel electrophoresis was used to characterize LDL subclasses in nonfasting blood samples from 72 MI cases and 159 controls aged 20-44 years. Mean LDL particle size in cases was significantly smaller compared with controls (26.4 vs. 26.9 nm, p < 0.001), with an odds ratio of 2.3 (p < 0.0001) for a 1-nm smaller LDL particle size. These results were independent of age, menopausal status, smoking, diabetes, hypertension, and LDL cholesterol (odds ratios = 1.9-2.3 for a l-nm smaller LDL particle size, all p < 0.02) but were not independent of body mass index, high density lipoprotein cholesterol, or triglyceride (odds ratios = 1.4, 1.4, and 1.1, respectively; all p > 0.05). Therefore, in age-adjusted analyses, smaller LDL particle size was associated with MI in young women, but the risk was attenuated after adjustments for metabolic factors related to both LDL particle size and MI.