Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation
Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation
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DOI：
10.1002/jcb.10435
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发表时间：
2003-04-01
影响因子：
4
通讯作者：
Einhorn, TA
中科院分区：
文献类型：
--
作者：
Gerstenfeld, LC;Cullinane, DM;Einhorn, TA
骨折愈合是一个专门的产后修复过程，概括了胚胎骨骼发育的各个方面。虽然许多控制细胞分化和生长的分子机制在胚胎发生过程中复发骨折愈合，这些过程发生在出生后的环境是独特的，不同于那些存在于胚胎发生过程中。这篇前景文章将突出一些中央生物过程，被认为是至关重要的胚胎分化和骨骼组织的生长，并审查这些过程在骨折愈合过程中的功能作用。与胚胎发育有关的骨折愈合的具体方面包括：（1）愈合过程中骨折骨痂的解剖结构;（2）促进修复过程的干细胞和形态发生信号的起源;（3）修复过程中生物力学环境在控制细胞分化中的作用;（4）骨折愈合过程中细胞的分化。（4）在修复过程中可溶性因子、促炎细胞因子、TGF-β超家族和血管生成因子的三个关键组的作用;和（5）控制骨量和重塑的遗传组分与响应于骨折控制骨骼组织修复的机制的关系。(C)2003 Wiley-Liss，Inc.
Fracture healing is a specialized post-natal repair process that recapitulates aspects of embryological skeletal development. While many of the molecular mechanisms that control cellular differentiation and growth during embryogenesis recur during fracture healing, these processes take place in a post-natal environment that is unique and distinct from those which exist during embryogenesis. This Prospect Article will highlight a number of central biological processes that are believed to be crucial in the embryonic differentiation and growth of skeletal tissues and review the functional role of these processes during fracture healing. Specific aspects of fracture healing that will be considered in relation to embryological development are: (1) the anatomic structure of the fracture callus as it evolves during healing; (2) the origins of stem cells and morphogenetic signals that facilitate the repair process; (3) the role of the biomechanical environment in controlling cellular differentiation during repair; (4) the role of three key groups of soluble factors, pro-inflammatory cytokines, the TGF-beta superfamily, and angiogenic factors, during repair; and (5) the relationship of the genetic components that control bone mass and remodeling to the mechanisms that control skeletal tissue repair in response to fracture. (C) 2003 Wiley-Liss, Inc.