Lactate stress testing in 155 patients with mitochondriopathy
Lactate stress testing in 155 patients with mitochondriopathy
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DOI：
10.1017/s0317167100001712
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发表时间：
2002-02-01
影响因子：
3
通讯作者：
Milvay, E
中科院分区：
文献类型：
--
作者：
Finsterer, J;Milvay, E
目的：关于乳酸负荷试验（LST）在一大群糖尿病（MCP）患者中的诊断率，目前几乎没有数据。研究方法：对62名年龄在17岁至84岁之间的对照组、155名年龄在17岁至87岁之间的MCP患者和31名患有神经系统疾病的患者在骑自行车15分钟、恒定30 W工作负荷之前、期间和之后分别测定了一次血清乳酸盐。除了MCP之外。结果如下：静息时、运动开始后5分钟、10分钟、15分钟和运动结束后15分钟的乳酸参考上限分别为2.0、2.1、2.1和1.8 mmol/l。如果5个乳酸值中有2个以上超过临界值，则认为该试验异常。在103例LST异常的患者中，64例（62%）静息乳酸正常。该试验的敏感性为67%，特异性为94%。结论：LST被证明在检测MCP患者中具有高灵敏度和特异性，因此是评估MCP患者中受损的氧化代谢的简单但有力的工具。
Objective: Few data are available about the diagnostic yield of the lactate stress test (LST) in a large group of patients with mitochondriopathy (MCP). Methods: Serum lactate was determined once before, three times during, and once after a 15-minute, constant 30W workload on a bicycle in 62 controls, aged 17 to 84 years, 155 patients With MCP, aged 17 to 87 years, and 31 patients with neurological disorders other than MCP. Results: Lactate's upper reference limits at rest, 5, 10, 15 minutes after starting, and 15 minutes after finishing the exercise were 2.0, 2.1, 2.1, 2.1 and 1.8 mmol/l respectively. The test was regarded abnormal if more than two of the five lactate values exceeded the cut-off levels. Among the 103 patients with abnormal LST, 64 (62%) had normal resting lactate. The sensitivity of the test was 67% and the specificity 94%. Conclusion: The LST proved to have a high sensitivity and specificity in the detection of patients with MCP being thus a simple but powerful tool to assess the impaired oxidative metabolism in MCP patients.