The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis
The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis
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DOI：
10.1007/s12282-011-0321-2
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发表时间：
2012-04-01
期刊：
影响因子：
4
通讯作者：
Inoue, Yasumichi
中科院分区：
文献类型：
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作者：
Imamura, Takeshi;Hikita, Atsuhiko;Inoue, Yasumichi
转化生长因子-β配体是一种多功能的生长因子，调节细胞的增殖、分化、迁移和凋亡等多种细胞行为。由于转化生长因子-β是一种强有力的生长抑制因子，转化生长因子-β信号的异常会导致肿瘤的发生。除了肿瘤抑制功能外，转化生长因子-β也是一种致癌因子。特别是，转化生长因子-β信号在乳腺癌的转移过程中起着重要作用。近年来，上皮-间充质转化(EMT)被证明具有细胞运动和对癌细胞侵袭性等恶性特性，并在肿瘤转移过程中发挥重要作用。此外，乳房干细胞样细胞具有EMT特性。由于转化生长因子-β是EMT和细胞干性的有效调节因子，转化生长因子-β信号可能在乳腺癌干细胞的调控中起着关键作用。
Transforming growth factor-beta (TGF-beta) ligand is a multifunctional growth factor that regulates various cell behavior, such as cell proliferation, differentiation, migration, and apoptosis. Because TGF-beta is a potent growth inhibitor, abnormalities in TGF-beta signaling result in carcinogenesis. In addition to tumor suppressor function, TGF-beta acts as an oncogenic factor. In particular, TGF-beta signaling plays an important role during metastasis of breast cancer. Recently, epithelial-mesenchymal transition (EMT) has been shown to confer malignant properties such as cell motility and invasiveness to cancer cells and plays crucial roles during cancer metastasis. Moreover, breast stem-like cells exhibit EMT properties. Because TGF-beta is a potent regulator of EMT as well as cell stemness, TGF-beta signaling might play a crucial role in the regulation of breast cancer stem cells.