Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients
Association of Adipocytokines With Carotid Intima Media Thickness and Arterial Stiffness in Obstructive Sleep Apnea Patients
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DOI：
10.3389/fendo.2020.00177
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发表时间：
2020-04-02
影响因子：
5.2
通讯作者：
Yi, Hongliang
中科院分区：
文献类型：
--
作者：
Song, Fan;Zou, Juanjuan;Yi, Hongliang
目的：阻塞性睡眠呼吸暂停(OSA)可导致颈动脉内膜-中层厚度(IMT)和动脉硬化，但脂肪细胞因子与OSA患者颈动脉内膜-中层厚度(IMT/AS)的关系尚不清楚。所有受试者都接受了颈动脉超声检查和多导睡眠图检查。用血样测定血清趋化蛋白、脂联素、SFRP5和apelin水平。用皮尔逊系数或斯皮尔曼系数评估两个定量变量之间的相关性。结果：OSA组IMT显著高于非鼾症组。动脉硬度参数如扩张性系数(DC)、顺应性系数(CC)、脉搏波速度(PWV)差异有统计学意义。OSA组SFRP5水平低于非鼾症组。在OSA患者中，脂联素与CC、DC和PWV相关，但在多变量调整后，这种关系消失了。年龄与所有定量的IMT和僵硬指数独立相关。AHI和最低血氧饱和度(Mini Sao(2))与动脉硬化独立相关。结论：OSA患者颈动脉弹性和定量IMT显著降低。年龄是与定量IMT和动脉僵硬相关的主要独立因素，AHI和Mini SaO(2)是相关因素。上述脂肪细胞因子与定量IMT/颈动脉硬度之间无相关性。
Objective: Obstructive sleep apnea (OSA) results in increased carotid intima-media thickness (IMT) and arterial stiffness; however, the association between adipocytokines and IMT/arterial stiffness in OSA patients is unclear.Methods: We enrolled 95 normal weight and overweight, not obese, participants from May 2018 to December 2018 in this study. All subjects underwent a carotid artery ultrasound examination and polysomnography. Blood samples were used to determine serum chemerin, adiponectin, SFRP5, and apelin levels. Correlations between two quantitative variables were assessed using the Pearson or Spearman coefficient. Stepwise models of multiple linear regression analysis were performed to assess the independent relationships.Result: IMT in OSA patients was significantly higher than in the non-snorers. There were significant differences in the arterial stiffness parameters such as distensibility coefficient (DC), compliance coefficient (CC), and pulse wave velocity (PWV). SFRP5 level was lower in OSA patients than in non-snorers. Adiponectin correlated with CC, DC, and PWV among OSA patients; however, the relationship disappeared after a multivariable adjustment. Age was independently associated with all quantitative IMT and stiffness indices. AHI and minimum oxygen saturation (Mini SaO(2)) were independently related to arterial stiffness.Conclusion: The quantitative IMT and carotid arterial elasticity were significantly worse among OSA patients. Age was the main independent factor correlated with quantitative IMT and arterial stiffness, and AHI and mini SaO(2) were associated factors. There were no relationships between aforementioned adipocytokines and quantitative IMT/carotid arterial stiffness.