Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana
Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana
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DOI：
10.1248/cpb.51.857
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发表时间：
2003-07-01
影响因子：
1.7
通讯作者：
Suksamrarn, A
中科院分区：
文献类型：
--
作者：
Suksamrarn, S;Suwannapoch, N;Suksamrarn, A
从芒果果的果壳、可食用的果皮和种子中分离得到的丙二酰基口山酮，对其抗结核活性进行了研究。α-和β-山竹黄素和山竹内酯B对结核分枝杆菌有较强的抑制作用，最低抑菌浓度(MIC)为6.25微克/毫升，含二碳五基或含C-5和修饰C-5基团的三氧和四氧杂多酮是抗结核活性所必需的。A环和C环上的取代已被证明可以改变化合物的生物活性。
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. alpha- and beta-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 mug/ml. Tri- and tetra-oxygenated xanthones with di-C-5 units or with a C-5 and a modified C-5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.