Curtailed respiration by repeated vs. isolated hypoxia in maturing piglets is unrelated to NTS ME or SP levels.
Curtailed respiration by repeated vs. isolated hypoxia in maturing piglets is unrelated to NTS ME or SP levels.
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成熟仔猪中反复缺氧与孤立缺氧导致的呼吸减少与 NTS ME 或 SP 水平无关。
DOI：
10.1152/jappl.1997.83.2.522
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Moss,IR
中科院分区：
文献类型：
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作者：
Waters,KA;Laferrière,A;Paquette,J;Goodyer,C;Moss,IR
沃茨，凯伦A.，Andre 'Laferrie Zagre，Julie Paquette，Cynthia Goodyer，and Immanuela R. Moss.在成熟仔猪中通过重复与孤立缺氧减少呼吸与NTS ME或SP水平无关.J. Appl. Physiol.83（2）：522-529，1997.-在早期发育过程中，呼吸系统疾病会在睡眠中产生反复的缺氧发作。为了检查每日重复与隔离低氧缺氧的可能影响，在21至32日龄、长期使用仪器、未镇静的仔猪中，比较了第五次连续每日低氧和隔离低氧（10%O2 - 90%N2，持续30分钟）之间的心肺功能和中枢神经系统相关神经调质水平。膈肌肌电图活动，心率和动脉压，pH值和气体张力进行了测量。在体内微透析，通过长期植入的指南，担任样品间质物质P（SP）和甲硫氨酸脑啡肽（ME）的水平上的神经系统相关的孤束核（NTS）。与单纯缺氧相比，反复缺氧可导致1）呼吸频率（f）、通气当量和动脉pH值降低，动脉pH值升高，低氧恢复期f降低; 2）SP浓度升高，ME浓度无变化。我们的结论是，在这些成熟的猪，重复与孤立的缺氧暴露减少呼吸反应缺氧的机制无关的SP或ME水平在NTS。
Waters, Karen A., André Laferrière, Julie Paquette, Cynthia Goodyer, and Immanuela R. Moss.Curtailed respiration by repeated vs. isolated hypoxia in maturing piglets is unrelated to NTS ME or SP levels.J. Appl. Physiol.83(2): 522–529, 1997.—In early development, respiratory disorders can produce recurring hypoxic episodes during sleep. To examine possible effects of daily repeated vs. isolated hypoxic hypoxia, cardiorespiratory functions and central, respiratory-related neuromodulator levels in 21- to 32-day-old, chronically instrumented, unsedated piglets were compared between a fifth sequential daily hypoxia and an isolated hypoxia (10% O2-90% N2for 30 min). Diaphragmatic electromyographic activity, heart rate and arterial pressure, and pH and gas tensions were measured. In vivo microdialysis, via chronically implanted guides, served to sample interstitial substance P (SP) and methionine-enkephalin (ME) at the level of the respiratory-related nucleus tractus solitarii (NTS). Compared with an isolated hypoxia, repeated hypoxia resulted in1) lower respiratory frequency (f), ventilation equivalent, and arterial pH, higher arterialduring hypoxia, and lower f in recovery from hypoxia; and2) increased SP concentrations but no change in ME concentrations. We conclude that, in these maturing swine, repeated vs. isolated hypoxic exposure curtails respiratory responses to hypoxia by a mechanism(s) unrelated to SP or ME levels at the NTS.