A comparative evaluation of the anticancer properties of European and American elderberry fruits.
A comparative evaluation of the anticancer properties of European and American elderberry fruits.
复制标题
欧洲和美国接骨木浆果抗癌特性的比较评价。
DOI：
10.1089/jmf.2006.9.498
复制
发表时间：
2006
影响因子：
2.4
通讯作者：
Lila,MaryAnn
中科院分区：
文献类型：
--
作者：
Thole,JulieM;Kraft,TristanFBurns;Sueiro,LillyAnn;Kang,Young-Hwa;Gills,JoellJ;Cuendet,Muriel;Pezzuto,JohnM;Seigler,DavidS;Lila,MaryAnn
European elderberry (Sambucus nigra), recognized in Europe for its health-promoting properties for many generations, is known to contain a range of anthocyanins, flavonoids, and other polyphenolics that contribute to the high antioxidant capacity of its berries. American elderberry (Sambucus canadensis), on the other hand, has not been cultivated, bred, and promoted as a medicinal plant like its better-characterized European counterpart. In this study, aqueous acetone extracts of the berries from these two species were fractionated and tested in a range of assays that gauge anticarcinogenic potential. Both cultivatedS. nigraand wildS. canadensisfruits demonstrated significant chemopreventive potential through strong induction of quinone reductase and inhibition of cyclooxygenase-2, which is indicative of anti-initiation and antipromotion properties, respectively. In addition, fractions ofS. canadensisextract showed inhibition of ornithine decarboxylase, an enzyme marker related to the promotion stage of carcinogenesis. Analysis of active fractions using mass spectrometry and liquid chromatography-mass spectrometry revealed, in addition to flavonoids, the presence of more lipophilic compounds such as sesquiterpenes, iridoid monoterpene glycosides, and phytosterols.
