Ectopic hCGβ expression by epithelial cancer:: Malignant behaviour, metastasis and inhibition of tumor cell apoptosis
Ectopic hCGβ expression by epithelial cancer:: Malignant behaviour, metastasis and inhibition of tumor cell apoptosis
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DOI：
10.1016/j.mce.2006.02.019
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发表时间：
2007-01-02
影响因子：
4.1
通讯作者：
Iles, R. K.
中科院分区：
文献类型：
--
作者：
Iles, R. K.
人绒毛膜促性腺激素（hCG）的β亚基的异位表达现在是20 - 40%的所有常见上皮癌中公认的现象，所述上皮癌产生于粘膜上皮，例如膀胱、子宫颈、肺和鼻咽。最近的研究表明，它作为一种自分泌生长因子，通过抑制细胞凋亡。结构同源性和体外研究表明，它可以通过抑制转化生长因子β（TGF β）受体复合物来实现这一点。这种分子机制将在某种程度上解释异位hCG β与预后不良和肿瘤迅速发展为转移的关系。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Ectopic expression of the beta-subunit of human chorionic gonadotropin (hCG) is now a recognized phenomenon in 20-40% of all common epithelial carcinoma arising from mucosal epithelia such as bladder, cervix, lung and naso-pharynx. Recent studies have shown that it acts as an autocrine growth factor by inhibiting apoptosis. Structural homology and in vitro studies suggest that it may achieve this by inhibition of the transforming growth factor beta (TGF beta) receptor complex. Such a molecular mechanism would go some way to explaining ectopic hCG beta's association with poor prognosis and tumors that will rapidly progress to metastasis. (c) 2006 Elsevier Ireland Ltd. All rights reserved.