Articular cartilage degradation in osteoarthritis.
Articular cartilage degradation in osteoarthritis.
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DOI：
10.1007/s11420-011-9250-z
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发表时间：
2012-02-01
期刊：
影响因子：
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通讯作者：
Goldring, Mary B
中科院分区：
文献类型：
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作者：
Goldring, Mary B
成人关节软骨的组成和细胞组织非常复杂，从浅表到深层以及域间和域或细胞周区域之间的基质成分存在定性和定量差异。软骨细胞是关节软骨的独特细胞成分，在正常、低周转条件下维持基质成分，其中蛋白聚糖和其他非胶原分子上的糖胺聚糖可以被替换。细胞周基质也很重要，含有 VI 型胶原蛋白、纤维调节蛋白和基质蛋白 3 等成分，但很少或没有 II 型胶原蛋白。
The composition and cellular organization of human adult articular cartilage are complex with qualitative and quantitative differences in matrix constituents ranging from the superficial through deep zones and between the interterritorial and territorial, or pericellular, regions. Chondrocytes, the unique cellular component of articular cartilage, maintain the matrix components under normal, low turnover conditions in which the glycosaminoglycans on proteoglycans and other noncollagen molecules can be replaced. The pericellular matrix is also important, with constituents such as collagen VI, fibromodulin, and matrilin 3, but little or no type II collagen.