Asymptomatic Cerebral Microbleeds Seen in Healthy Subjects Have a Strong Association With Asymptomatic Lacunar Infarction
Asymptomatic Cerebral Microbleeds Seen in Healthy Subjects Have a Strong Association With Asymptomatic Lacunar Infarction
复制标题
DOI：
10.1253/circj.cj-08-0764
复制
发表时间：
2009-03-01
影响因子：
3.3
通讯作者：
Miki, Tetsuro
中科院分区：
文献类型：
--
作者：
Igase, Michiya;Tabara, Yasuharu;Miki, Tetsuro
背景资料。脑微出血(CMB)是脑出血(ICH)的危险因素之一，在梯度回波T2加权磁共振成像上表现明显。即使在神经学健康的人中也发现了CMBS，这些人似乎也容易受到中风的影响，不仅是脑出血，还包括脑梗塞。方法和结果：调查了脑对接受试者中CMB的存在，参照无症状性腔隙梗死(SLI)。参与者包括377名神经健康的人，其中21人(5.6%)检测到CMB，这与高血压的高发病率有关，其他传统危险因素与CMB没有显著相关性。在简单的相关分析中，CMB与年龄和收缩压(SBP)呈正相关。Logistic回归分析显示SLI是与CMB关系最密切的因素。结论：CMB的病因与SLI的病因相似。(保监会J 2009；73：530-533)
Background. Cerebral microbleed (CMB), which is conspicuous on gradient-echo T2*-weighted magnetic resonance imaging, is a risk factor of intracerebral hemorrhage (ICH). CMBs have been detected even in neurologically healthy persons, who also seem prone to be affected by stroke, not only ICH but also cerebral infarction.Methods and Results: The presence of CMB was investigated in brain dock participants, making reference to silent lacunar infarction (SLI). Participants comprised 377 neurologically healthy persons and 21 (5.6%) had CMB detected, which was associated with a high incidence of hypertension, other conventional risk factors having no significant correlation with CMB. In a simple correlation analysis, CMB showed a positive association with age and systolic blood pressure (SBP). Logistic regression analysis revealed that SLI was the factor most strongly associated with CMB. Moreover, individuals who had both CMB and SLI had higher SBP than other groups.Conclusions: The etiology of CMB is similar to that of SLI. (Circ J 2009; 73: 530-533)