Targeting the formation of the cell wall core of M. tuberculosis.
Targeting the formation of the cell wall core of M. tuberculosis.
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DOI：
10.2174/187152607781001808
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发表时间：
2007-05
期刊：
影响因子：
--
通讯作者：
C. Barry;D. Crick;M. McNeil
中科院分区：
文献类型：
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作者：
C. Barry;D. Crick;M. McNeil
分枝杆菌具有独特的细胞壁，这是丰富的药物靶点。细胞壁核心由肽聚糖层、分枝菌酸层和连接它们的阿拉伯半乳聚糖多糖组成。细胞壁核心的详细结构虽然不完全，但在很大程度上是理解的，并且将被呈现。所有三种组分的生物合成途径揭示了重要的药物靶点，这些靶点是现有药物的基础和/或具有新药的潜力。这些途径将进行审查，包括酶参与聚异戊二烯生物合成，可溶性阿拉伯半乳聚糖前体生产，阿拉伯半乳聚糖聚合，脂肪酸合成，霉菌酸成熟，可溶性肽聚糖前体形成。与靶向所有这些酶相关的信息将以表格形式呈现。然后将更详细地讨论所选择的酶。因此，希望本章将有助于选择新的药物，以打击结核病的目标。
Mycobacteria have a unique cell wall, which is rich in drug targets. The cell wall core consists of a peptidoglycan layer, a mycolic acid layer, and an arabinogalactan polysaccharide connecting them. The detailed structure of the cell wall core is largely, although not completely, understood and will be presented. The biosynthetic pathways of all three components reveal significant drug targets that are the basis of present drugs and/or have potential for new drugs. These pathways will be reviewed and include enzymes involved in polyisoprene biosynthesis, soluble arabinogalactan precursor production, arabinogalactan polymerization, fatty acid synthesis, mycolate maturation, and soluble peptidoglycan precursor formation. Information relevant to targeting all these enzymes will be presented in tabular form. Selected enzymes will then be discussed in more detail. It is thus hoped this chapter will aid in the selection of targets for new drugs to combat tuberculosis.