Early-onset dementia: Frequency and causes compared to late-onset dementia
Early-onset dementia: Frequency and causes compared to late-onset dementia
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DOI：
10.1159/000089546
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发表时间：
2006-01-01
影响因子：
2.4
通讯作者：
Mendez, MF
中科院分区：
文献类型：
--
作者：
McMurtray, A;Clark, DG;Mendez, MF
背景：痴呆症的流行病学研究主要集中在老年人身上。很少有调查研究早发性痴呆（EOD），发病年龄小于65岁，和更常见的晚发性疾病之间的病因频率的差异。目的：要确定相对频率和特点EOD与晚发性痴呆（LOD;发病年龄6 - 65岁）诊断在一个大型记忆障碍计划超过4年的时间。研究方法：我们回顾了2001年至2004年期间在退伍军人事务医疗中心记忆障碍诊所就诊的所有患者的病历，包括广泛的神经行为和神经系统评估，并评估了人口统计学变量、最终诊断、痴呆的存在和痴呆疾病的鉴别诊断。结果如下：在1,683名接受记忆或认知获得性下降评估的患者中，948名（56%）符合痴呆疾病的既定临床标准。其中约30%（n = 278）的发病年龄为
Background: Research on the epidemiology of dementia has focused on the elderly. Few investigations have studied differences in etiologic frequencies between early-onset dementia (EOD), with onset at an age of less than 65 years old, and the more common late-onset disorder. Objectives: To determine relative frequencies and characteristics of EOD versus late-onset dementia (LOD; age of onset 6 65 years) diagnosed in a large memory disorders program over a 4-year period. Methods: We reviewed medical records, including an extensive neurobehavioral and neurological evaluation, of all patients seen at a large Veteran's Affairs Medical Center Memory Disorders clinic between 2001 and 2004 and assessed demographic variables, final diagnoses, presence of dementia, and differential diagnosis of dementing illnesses. Results: Among 1,683 patients presenting for evaluation of an acquired decline in memory or cognition, 948 (56%) met established clinical criteria for a dementing illness. About 30% (n = 278) of these had an age of onset of