A comparison between basilar membrane and inner hair cell receptor potential input-output functions in the guinea pig cochlea.
A comparison between basilar membrane and inner hair cell receptor potential input-output functions in the guinea pig cochlea.
复制标题
豚鼠耳蜗基底膜和内毛细胞受体电位输入输出功能的比较。
DOI：
10.1121/1.390282
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
P. Sellick
中科院分区：
文献类型：
--
作者：
R. Patuzzi;P. Sellick
用内毛细胞作细胞内记录，在相同的位置测量基底膜的运动，但在不同的准备下，在豚鼠的第一个耳蜗圈。使用玻璃微电极进行电位记录，并使用穆斯堡尔技术进行机械测量。给出了具有良好阈值和较差阈值的动物的DC受体电位和基底膜速度的强度函数。在具有良好阈值的动物中，特征频率以上的刺激对内毛细胞感受器电位和基底膜运动产生类似的压缩输入输出功能。然而，对于低于特征频率的频率，从良好和恶劣状态下获得的动物的感受器电位输入输出函数在高刺激强度下呈现饱和，在该刺激强度下，基底膜呈线性运动。这种差异被认为是由于一种非线性的内毛细胞转导机制。我们认为，感受器电位输入-输出函数中观察到的非线性是频率相关的非线性机械输入和频率无关的非线性信号传递过程的简单级联的结果。
Intracellular recordings were made from inner hair cells and basilar membrane motion was measured at a similar place, but in different preparations, in the first turn of the guinea pig cochlea. Potential recordings were made using glass microelectrodes and mechanical measurements were made using the Mössbauer technique. Intensity functions of DC receptor potential and basilar membrane velocity in animals with good and poor thresholds are presented. In animals with good thresholds, stimuli at and above the characteristic frequency produce similarly compressive input-output functions for both inner hair cell receptor potentials and basilar membrane motion. However, for frequencies lower than the characteristic frequency, receptor potential input-output functions obtained from animals in good and poor condition show saturation at high stimulus intensities at which basilar membrane motion is linear. This discrepancy is believed to be due to a nonlinear inner hair cell transduction mechanism. We propose that nonlinearity observed in receptor potential input-output functions is a consequence of the simple cascading of a frequency-dependent nonlinear mechanical input and a frequency-independent nonlinear transduction process.