Assessment of angiogenesis modulators in pregnant women with pre-eclampsia: a case-control study
Assessment of angiogenesis modulators in pregnant women with pre-eclampsia: a case-control study
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DOI：
10.1007/s00404-015-3823-x
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发表时间：
2016-02-01
影响因子：
2.6
通讯作者：
Rodrigues Junior, Virmondes
中科院分区：
文献类型：
--
作者：
Mundim, Guilhermo Justino;Paschoini, Marina Carvalho;Rodrigues Junior, Virmondes
This study aimed to evaluate the serum concentration of factors associated with placental angiogenesis in pre-eclamptic and normotensive pregnant women.This was a prospective, cross-sectional, case-control study in which the pro-angiogenic factors PlGF, VEGF and IL-10, and the anti-angiogenic factors IL-6, IL-17 and TNF-alpha of 55 pregnant women (31 with pre-eclampsia-PE and 24 normotensive), with gestational age a parts per thousand yen20 weeks, were measured in maternal blood through the enzyme-linked immunosorbent assay (ELISA). The Mann-Whitney and Kruskal-Wallis tests were used for comparison between groups.Serum PIGF was reduced in the group of pregnant women with PE when compared with the normotensive women (493.2 +/- A 55.1 pg/mL vs. 4.4 +/- A 26.5 pg/mL; p < 0.001). There was no significant difference in PlGF levels in the pre-eclamptic pregnant women in relation to gestational age or proteinuria levels (p > 0.05). The serum levels of VEGF, IL-17, IL-10 and TNF-alpha were lower in the pregnant women with PE when compared with their normotensive peers, while the IL-6 levels were higher; however, this difference was not statistically significant (p > 0.05).Serum PlGF levels were reduced in the pregnant women with PE and were unrelated to disease severity. Serum levels of VEGF, IL-17, IL-10 and TNF-alpha were reduced in the pre-eclamptic pregnant women when compared with their normotensive peers, without statistically significant differences.
